ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Excitatory/Inhibitory Responses Shape Coherent Neuronal Dynamics Driven by Optogenetic Stimulation in the Primate Brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A causal role for the posterior corpus callosum in bimanual coordination.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Resting state fMRI-based temporal coherence mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Putative cell-type-specific multiregional mode in posterior parietal cortex during coordinated visual behavior.Neuron · 2023Article
- Controlling neocortical epileptic seizures using forced temporal spike-time stimulation: anFrontiers in computational neuroscience · 2023Article
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Dose-response relationship between the variables of unilateral optogenetic stimulation and transcallosal evoked responses in rat motor cortex.Frontiers in neuroscience · 2022Article
- Marmosets: a promising model for probing the neural mechanisms underlying complex visual networks such as the frontal-parietal network.Brain structure & function · 2021Review
- Assessment of optogenetically-driven strategies for prosthetic restoration of cortical vision in large-scale neural simulation of V1.Scientific reports · 2021Article
- Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases.Annual review of pharmacology and toxicology · 2021Review
- Article
- Light Up the Brain: The Application of Optogenetics in Cell-Type Specific Dissection of Mouse Brain Circuits.Frontiers in neural circuits · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Coherent neuronal dynamics play an important role in complex cognitive functions. Optogenetic stimulation promises to provide new ways to test the functional significance of coherent neural activity. However, the mechanisms by which optogenetic stimulation drives coherent dynamics remain unclear, especially in the nonhuman primate brain. Here, we perform computational modeling and experiments to study the mechanisms of optogenetic-stimulation-driven coherent neuronal dynamics in three male nonhuman primates. Neural responses arise from stimulation-evoked, temporally dynamic excitatory (E) and inhibitory (I) activity. Spiking activity is more likely to occur during E/I imbalances. Thus the relative difference in the driven E and I responses precisely controls spike timing by forming a brief time interval of increased spiking likelihood. Experimental results agree with parameter-dependent predictions from the computational models. These results demonstrate that optogenetic stimulation driven coherent neuronal dynamics are governed by the temporal properties of E/I activity. Transient imbalances in excitatory and inhibitory activity may provide a general mechanism for generating coherent neuronal dynamics without the need for an oscillatory generator.
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