Evidence map›Paper›PMID 31964715›Full record

ArticleThe Journal of biological chemistry2020

Mechanism underlying autoinducer recognition in the

Xiuliang Huang, Olivia P Duddy, Justin E Silpe, Jon E Paczkowski, Jianping Cong, Brad R Henke, Bonnie L Bassler

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. mBio · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Non-O1/Non-O139Microorganisms · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Natural Silencing of Quorum-Sensing Activity ProtectsbioRxiv : the preprint server for biology · 2023
    Article
  12. Small regulatory RNAs inmicroLife · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. PAS domains in bacterial signal transduction.Current opinion in microbiology · 2021
    Review
  17. Article
  18. Chemical Control of Quorum Sensing inACS infectious diseases · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiuliang HuangDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815.
Olivia P DuddyDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544.
Justin E SilpeDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544.
Jon E PaczkowskiDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544.
Jianping CongDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815.
Brad R HenkeOpti-Mol Consulting, LLC, Cary, North Carolina 27513.
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815. Electronic address: bbassler@princeton.edu.
Howard Hughes Medical Institute · USPrinceton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Howard Hughes Medical InstituteNIGMS NIH HHS P41 GM111244NIGMS NIH HHS R37 GM065859NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Quorum sensing is a bacterial communication process whereby bacteria produce, release, and detect extracellular signaling molecules called autoinducers to coordinate collective behaviors. In the pathogen

Indexed as

Quorum SensingSignal TransductionBacterial ProteinsBinding SitesCrystallography, X-RayDNAGene Expression Regulation, BacterialLigandsMolecular Dynamics SimulationMutagenesis, Site-DirectedProtein BindingPyrazolesStructure-Activity RelationshipTranscription FactorsVibrio cholerae3,5-dimethylpyrazin-2-olBacterial ProteinsDNALigandsPyrazolesTranscription Factors3,5-dimethyl-pyrazin-2-ol (DPO)autoinducerbacteriabindingcrystallographygene regulationN-alanyl-aminoacetone (Ala-AA)quorum sensingVibrio choleraeVqmA

Identifiers

PMID31964715
PMCPMC7062168
OpenAlexW3002320125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.