Evidence map›Paper›PMID 31964686›Full record

ArticleeNeuro

Cannabinoid Signaling Recruits Astrocytes to Modulate Presynaptic Function in the Suprachiasmatic Nucleus.

Lauren M Hablitz, Ali N Gunesch, Olga Cravetchi, Michael Moldavan, Charles N Allen

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

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  15. Cannabinoids, Endocannabinoids and Sleep.Frontiers in molecular neuroscience · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lauren M HablitzOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.ORCID 0000-0001-6159-7742
Ali N GuneschOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Olga CravetchiOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Michael MoldavanOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.ORCID 0000-0003-4039-0325
Charles N AllenOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239 allenc@ohsu.edu.ORCID 0000-0002-3689-2878
Oregon Health & Science University · US

Funding

BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Mechanisms of GABAergic Signaling in the Suprachiasmatic Nucleus NetworkR01NS103842 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLEN, CHARLES N · 2018 to 2025
$4.0M
Opioid Sensitive GABA inputs to the Ventral MidbrainR01DA034388 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 2012 to 2016
$967k
Laser Scanning Confocal MicroscopeS10RR025440 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI BARR-GILLESPIE, PETER GORDON · 2009 to 2009
$368k
NCRR NIH HHS S10 RR025440NIDA NIH HHS R01 DA034388NIDA NIH HHS T32 DA007262NINDS NIH HHS P30 NS061800NINDS NIH HHS R01 NS103842
6 · The paper itself

Abstract

Circadian rhythms are 24-h cycles in physiology regulated by the suprachiasmatic nucleus (SCN) in the brain, where daily cues act on SCN neurons to alter clock timing. Cannabinoid signaling modulates SCN neuronal activity, although the mechanism remains unclear. We propose that neuronal activity generates endocannabinoid release, activating astrocyte Ca

Indexed as

AstrocytesCannabinoidsCircadian ClocksAnimalsCircadian RhythmMiceSignal TransductionSuprachiasmatic NucleusCannabinoidsastrocytecircadian rhythmendocannabinoidGABAsuprachiasmatic nucleus

Identifiers

PMID31964686
PMCPMC7029187
OpenAlexW3002733293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.