ArticleBMJ open2020
Epidemiology of knee osteoarthritis in general practice: a registry-based study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05839262 (Physical Exercise Guided by Active Video Games for Optimizing Clinical and Psychosocial Outcomes in Older Adults With Knee and/or Hip Osteoarthritis Under a Community-based Rehabilitation Model.), which is not on this map. Cited by 59 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Exercise Guided by Active Video Games for Optimizing Clinical and Psychosocial Outcomes in Older Adults With Knee and/or Hip Osteoarthritis Under a Community-based Rehabilitation Model.
Who cites it
59 citing papers in PubMed, 7 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Prevalence of hip and knee osteoarthritis in Europe: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- The optimal course and frequency of Tai Chi for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- The effects of exercise training on knee repositioning sense in people with knee osteoarthritis: a systematic review and meta-analysis of clinical trials.BMC musculoskeletal disorders · 2023Pooled it
- Biopsychosocial, work-related, and environmental factors affecting work participation in people with Osteoarthritis: a systematic review.BMC musculoskeletal disorders · 2023Pooled it
- Can we distinguish the roles of demographic and temporal changes in the incidence and prevalence of musculoskeletal disorders? A systematic review.Scandinavian journal of work, environment & health · 2022Pooled it
- Effects of Whole-Body Vibration Therapy on Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of rehabilitation medicine · 2022Pooled it
- The association between alcohol consumption and osteoarthritis: a meta-analysis and meta-regression of observational studies.Rheumatology international · 2021Pooled it
- Efficacy of Adductor Canal Block on Medial Knee Pain in Patients with Knee Osteoarthritis: A Randomized Single-Blind Placebo-Controlled Study.International journal of environmental research and public health · 2022Trial
- Which matters more for preventing knee replacements: reducing overactivity or combating inactivity?Aging clinical and experimental research · 2026Article
- Comparison of innate and adaptive immune responses to joint injury during the onset and progression of post-traumatic osteoarthritis in common murine models.Scientific reports · 2026Article
- Unveiling sex- and side-specific variations in genicular nerve targeting: implications for precision in nerve ablation therapy.Surgical and radiologic anatomy : SRA · 2026Article
- Altered activation patterns of sensorimotor cortex during level walking and stair climbing in patients with knee osteoarthritis: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Article
- Evaluation of enhanced pain management programs for patients undergoing surgery for severe knee osteoarthritis: a retrospective study.Annals of medicine · 2025Article
- Article
- Does the cartilage proteome differ between osteoarthritic knees with varus and valgus deformities? Insights from proteomic analysis.Journal of orthopaedics · 2025Article
- Review
- Patterns of analgesic utilisation among people with knee osteoarthritis: a cohort study using UK primary care data.Journal of pharmaceutical policy and practice · 2025Article
- A new approach in the treatment of ultrasound-guided synovial hypertrophy.Turkish journal of medical sciences · 2025Article
- Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling.Inflammation and regeneration · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study investigated (1) trends in the prevalence and incidence of knee osteoarthritis over a 20-year period (1996-2015); (2) trends in multimorbidity and (3) trends in drug prescriptions.
designRegistry-based study.
settingPrimary healthcare, Flanders, Belgium.
participantsData were collected from Intego, a general practice-based morbidity registration network. In the study period between 1996 and 2015, data from 440 140 unique patients were available. OUTCOME MEASURES: Trends in prevalence and incidence rate of knee osteoarthritis were computed using joinpoint regression analysis. The mean disease count was calculated to assess trends in multimorbidity. In addition, the number of drug prescriptions was identified by the Anatomical Therapeutic Chemical Classification code and trends were equally recorded with joinpoint regression.
resultsThe total age-standardised prevalence of knee osteoarthritis increased from 2.0% in 1996 to 3.6% in 2015. An upward trend was observed with an average annual percentage change (AAPC) of 2.5 (95% CI 2.2 to 2.9). In 2015, the prevalence rates in the 10 year age groups from the 45-54 years age group onwards were 3.1%, 5.6%, 9.0% and 13.9%, to reach 15.0% in people aged 85 years and older. The incidence remained stable with 3.75‰ in 2015 (AAPC=-0.5, 95% CI -1.4 to 0.5). The mean disease count significantly increased from 1.63 to 2.34 (p<0.001) for incident cases with knee osteoarthritis. Finally, we observed a significantly positive trend in the overall prescription of acetaminophen (AAPC=6.7, 95% CI 5.6 to 7.7), weak opioids (AAPC=4.0, 95% CI 0.9 to 7.3) and glucosamine (AAPC=8.6, 95% CI 2.4 to 15.1). Oral non-steroidal anti-inflammatory drugs were most prescribed, with a prevalence rate of 29.8% in 2015, but remained stable during the study period (AAPC=0.0, 95% CI -1.1 to 1.1).
conclusionsIncreased prevalence, multimorbidity, and number of drug prescriptions confirm an increased burden of knee osteoarthritis. In future, these trends can be used to prioritise initiatives for improvement in care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.