Evidence map›Paper›PMID 31964647›Full record

ReviewCold Spring Harbor perspectives in medicine2021

Human Susceptibility to Influenza Infection and Severe Disease.

Robert C Mettelman, Paul G Thomas

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Influenza.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. ZBP1-driven cell death in severe influenza.Trends in microbiology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Influenza A infections: predictors of disease severity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  17. Article
  18. Article
  19. Cycling and activated CD8BMC immunology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert C MettelmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Paul G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
St. Jude Children's Research Hospital · US

Funding

Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7M
NIAID NIH HHS HHSN272201400006CNIAID NIH HHS U01 AI144616
6 · The paper itself

Abstract

Influenza viruses are a persistent threat to global human health. Increased susceptibility to infection and the risk factors associated with progression to severe influenza-related disease are determined by a multitude of viral, host, and environmental conditions. Decades of epidemiologic research have broadly defined high-risk groups, while new genomic association studies have identified specific host factors impacting an individual's response to influenza. Here, we review and highlight both human susceptibility to influenza infection and the conditions that lead to severe influenza disease.

Indexed as

Disease SusceptibilityPatient AcuityHost-Pathogen InteractionsHumansInfluenza, Human

Identifiers

PMID31964647
PMCPMC8091954
OpenAlexW3000905712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.