Evidence map›Paper›PMID 31964644›Full record

ReviewCold Spring Harbor perspectives in medicine2020

Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission.

William J Wright, Yan Dong

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Article
  3. Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  14. Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  15. Review
  16. Review
  17. Silent Synapses in Cocaine-Associated Memory and Beyond.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  18. Article
  19. AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William J WrightDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Yan DongDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Funding

Glial-mediated synaptic remodeling in drug addictionR01DA040620 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong, ERIC J. NESTLER · 2016 to 2026
$5.3M
Cocaine-induced adaptation in NMDA receptorsR37DA023206 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong · 2018 to 2026
$3.9M
Cocaine-induced Adaptation in NMDA Receptors in Nucleus AccumbensR01DA023206 · NIDA · WASHINGTON STATE UNIVERSITY · PI DONG, YAN · 2008 to 2017
$3.0M
Homeostatic Regulation and Dysregulation in Cocaine CravingR01DA034856 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONG, YAN · 2013 to 2017
$1.5M
Homeostatic Plasticity in Nucleus AccumbensR01DA030379 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONG, YAN, MALENKA, ROBERT C · 2013 to 2014
$880k
Circuitry Progression of Cocaine-induced Cellular AdaptationR21DA047861 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONG, YAN · 2019 to 2020
$430k
Glutamatergic signaling in accumbens astrocytesR21DA044538 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONG, YAN · 2017 to 2018
$399k
Fast-spiking interneurons in the Nucleus Accumbens and cue-induced cocaine seekingF31DA043940 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WRIGHT, WILLIAM JAMES · 2018 to 2021
$161k
NIDA NIH HHS F31 DA043940NIDA NIH HHS R01 DA023206NIDA NIH HHS R01 DA030379NIDA NIH HHS R01 DA034856NIDA NIH HHS R01 DA040620NIDA NIH HHS R21 DA044538NIDA NIH HHS R21 DA047861NIDA NIH HHS R37 DA023206
6 · The paper itself

Abstract

Carrying different aspects of emotional and motivational signals, glutamatergic synaptic projections from multiple limbic and paralimbic brain regions converge to the nucleus accumbens (NAc), in which these arousing signals are processed and prioritized for behavioral output. In animal models of drug addiction, some key drug-induced alterations at NAc glutamatergic synapses underlie important cellular and circuit mechanisms that promote subsequent drug taking, seeking, and relapse. With the focus of cocaine, we review changes at NAc glutamatergic synapses that occur after different drug procedures and abstinence durations, and the behavioral impact of these changes.

Indexed as

Synaptic TransmissionAnimalsCocaineExcitatory Amino Acid AgentsHumansNeural PathwaysNeuronal PlasticityNucleus AccumbensSubstance-Related DisordersCocaineExcitatory Amino Acid Agents

Identifiers

PMID31964644
PMCPMC7706579

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.