Evidence map›Paper›PMID 31964611›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2020

Mother-To-Child Transmission of HIV in Adolescents and Young Women: Findings From a National Prospective Cohort Survey, Zimbabwe, 2013-2014.

Amanda B Burrage, Angela Mushavi, Ray W Shiraishi, Beth Tippett Barr, Geral Shambira, Justice Nyakura, Shirish Balachandra, Peter H Kilmarx, Thu-Ha Dinh

Open access · greenAbstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Amanda B BurrageDivision of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Center for Global Health, Atlanta, Georgia.
Angela MushaviAIDS and TB Department, Ministry of Health and Child Care of Zimbabwe, Harare, Zimbabwe.
Ray W ShiraishiDivision of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Center for Global Health, Atlanta, Georgia.
Beth Tippett BarrDivision of Global HIV/AIDS, U.S. Centers for Disease Control and Prevention, Center for Global Health, Harare, Zimbabwe.
Geral ShambiraDepartment of Community Health, University of Zimbabwe, Harare, Zimbabwe.
Justice NyakuraDepartment of Community Health, University of Zimbabwe, Harare, Zimbabwe.
Shirish BalachandraDivision of Global HIV/AIDS, U.S. Centers for Disease Control and Prevention, Center for Global Health, Harare, Zimbabwe.
Peter H KilmarxDivision of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Center for Global Health, Atlanta, Georgia; Division of Global HIV/AIDS, U.S. Centers for Disease Control and Prevention, Center for Global Health, Harare, Zimbabwe.
Thu-Ha DinhDivision of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Center for Global Health, Atlanta, Georgia. Electronic address: dvt1@cdc.gov.
Center for Global Health · USUniversity of Zimbabwe · ZWMinistry of Health and Child Welfare · ZW

Funding

CGH CDC HHS U2G GH000315PEPFAR
6 · The paper itself

Abstract

purposeWe assessed 18-month cumulative mother-to-child HIV transmission (MTCT) risk and risk factors for no antiretroviral medication use during pregnancy among adolescent, young women, and adult mothers in Zimbabwe.

methodsWe analyzed data from a prospective survey of 1,171 mother-infant pairs with HIV-exposed infants aged 4-12 weeks who were recruited from 151 immunization clinics from February to August 2013. HIV-exposed infants were followed until diagnosed with HIV, death, or age 18 months. Findings were weighted and adjusted for complex survey design and nonresponse.

resultsThe 18-month cumulative MTCT risk was highest among adolescent aged ≤19 years (12%) followed by young women aged 20-24 years (7.5%) and adult women aged ≥25 years (6.9%). Across these groups, more than 94% had ≥1 antenatal care visit by 21 weeks of gestation, more than 95% had ≥1 HIV test, and more than 98% knew their HIV status. Of known HIV-positive mothers, maternal antiretroviral medication coverage during pregnancy was 76.8% (95% confidence interval: 65.1-85.5), 83.8% (78.6-87.9), and 87.8% (84.6-90.4) among adolescent, young women, and adult mothers, respectively. Among HIV-positive mothers diagnosed prenatally, the adjusted odds ratio of no ARV use during pregnancy was increased among those who had no antenatal care attendance (adjusted odds ratio: 7.7 [3.7-16.0]), no HIV testing (7.3 [2.3-23.5]), no prepartum CD4 count testing (2.1 [1.3-3.4]), and maternal HIV identification during pregnancy (2.9 [1.8-4.8]). Age was not a risk factor.

conclusionsWith similar coverage of prevention of MTCT services, the 18-month cumulative MTCT risk was higher among adolescents and young women, compared with adults. Additional research should examine the causes to develop targeted interventions.

Indexed as

AdolescentAdultAge DistributionChildChild, PreschoolFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaternal AgePregnancyPregnancy Complications, InfectiousProspective StudiesSocioeconomic FactorsYoung AdultAdolescentsMother-to-child HIV transmission (MTCT)Young womenZimbabwe

Identifiers

PMID31964611
PMCPMC8740363
OpenAlexW2998963633

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.