Evidence map›Paper›PMID 31964511›Full record

ArticleTrends in pharmacological sciences2020

Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens.

Sarah Zych, Christopher P Ford

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sarah ZychDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Christopher P FordDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: christopher.ford@cuanschutz.edu.

Funding

Encoding Dopamine Signals in the Mesolimbic SystemR01DA035821 · NIDA · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2013 to 2023
$3.5M
Regulation of striatal acetylcholine transmission by cholinergic interneuronsR01NS095809 · NINDS · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2016 to 2024
$3.4M
NINDS NIH HHS R01 NS095809
6 · The paper itself

Abstract

To investigate how opioid exposure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP sensor to track cAMP dynamics and report a coordinated effort of adaptations in D1- and D2-MSNs to integrate DA inputs and shift signaling strengths in various states of opioid dependence.

Indexed as

Nucleus AccumbensReceptors, Dopamine D1Analgesics, OpioidCorpus StriatumReceptors, Dopamine D2Analgesics, OpioidReceptors, Dopamine D1Receptors, Dopamine D2dopamineGPCRopioidstriatumstriosome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.