Evidence map›Paper›PMID 31964463›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2020

Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20.

Sofie Elisabeth Midgley, Kimberley Benschop, Robert Dyrdak, Audrey Mirand, Jean-Luc Bailly, Sibylle Bierbaum, Stefan Buderus, Sindy Böttcher, Anna-Maria Eis-Hübinger, Mario Hönemann and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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  20. Epidemiology of acute flaccid myelitis in children in the Netherlands, 2014 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 6 countries.

Sofie Elisabeth MidgleyDepartment for Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
Kimberley BenschopCentre for Infectious Disease Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Robert DyrdakDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Audrey MirandCHU Clermont-Ferrand, Centre National de Référence des entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France.
Jean-Luc BaillyUniversité Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France.
Sibylle BierbaumInstitute of Virology, University of Freiburg, Freiburg, Germany.
Stefan BuderusDepartment of General Pediatrics, St.-Marien-Hospital, Bonn, Germany.
Sindy BöttcherNational Reference Center for Poliomyelitis and Enteroviruses, Robert Koch-Institute, Berlin, Germany.
Anna-Maria Eis-HübingerInstitute of Virology, University of Bonn Medical Center, Bonn, Germany.
Mario HönemannInstitute of Virology, University of Leipzig, Leipzig, Germany.
Veronika Vorobieva JensenDepartment for Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
Ulla Birgitte HartlingDepartment of Paediatrics, Aarhus University Hospital, Aarhus, Denmark.
Cécile HenquellCHU Clermont-Ferrand, Centre National de Référence des entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France.
Marcus PanningInstitute of Virology, University of Freiburg, Freiburg, Germany.
Marianne Kragh ThomsenDepartment of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
Emma B HodcroftBiozentrum, University of Basel, Basel, Switzerland.
Adam MeijerCentre for Infectious Disease Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Aarhus University Hospital · DKCentre National de la Recherche Scientifique · FRNational Institute for Public Health and the Environment · NLStatens Serum Institut · DKUniversity of Freiburg · DECentre Hospitalier Universitaire de Clermont-Ferrand · FRKarolinska University Hospital · SELeipzig University · DERobert Koch Institute · DESIB Swiss Institute of Bioinformatics · CHSt. Marien-Hospital Bonn · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.

Indexed as

Disease OutbreaksAdolescentAdultAgedAged, 80 and overChildChild, PreschoolEnterovirus D, HumanEnterovirus InfectionsEuropeFemaleHumansInfantInfant, NewbornMaleMiddle Agedacute flaccid myelitisenterovirus D68novel strainssevere respiratory infectionsurveillance

Identifiers

PMID31964463
PMCPMC6976881
OpenAlexW3000322773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.