Evidence map›Paper›PMID 31964368›Full record

ArticleBMC pediatrics2020

Childhood overweight and obesity and the risk of depression across the lifespan.

Deborah Gibson-Smith, Thorhallur I Halldorsson, Mariska Bot, Ingeborg A Brouwer, Marjolein Visser, Inga Thorsdottir, Bryndis E Birgisdottir, Vilmundur Gudnason, Gudny Eiriksdottir, Lenore J Launer and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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  18. Biomechanical CT to Assess Bone After Sleeve Gastrectomy in Adolescents With Obesity: A Prospective Longitudinal Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Deborah Gibson-SmithDepartment of Health Sciences, University of York, York, UK. deborah.gibson-smith@york.ac.uk.ORCID 0000-0002-7552-500X
Thorhallur I HalldorssonUnit for Nutrition Research, Landspitali, The National University Hospital of Iceland and Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland.
Mariska BotDepartment of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands.
Ingeborg A BrouwerDepartment of Health Sciences, Faculty of Science and Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, the Netherlands, Vrije Universiteit Amsterdam, 1081, HV, Amsterdam, The Netherlands.
Marjolein VisserDepartment of Health Sciences, Faculty of Science and Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, the Netherlands, Vrije Universiteit Amsterdam, 1081, HV, Amsterdam, The Netherlands.
Inga ThorsdottirUnit for Nutrition Research, Landspitali, The National University Hospital of Iceland and Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland.
Bryndis E BirgisdottirUnit for Nutrition Research, Landspitali, The National University Hospital of Iceland and Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland.
Vilmundur GudnasonIcelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.
Gudny EiriksdottirIcelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.
Lenore J LaunerNational Institute on Aging, Laboratory of Epidemiology, and Population Sciences, 7201 Wisconsin Avenue, Bethesda, MD, 20892-9205, USA.
Tamara B HarrisNational Institute on Aging, Laboratory of Epidemiology, and Population Sciences, 7201 Wisconsin Avenue, Bethesda, MD, 20892-9205, USA.
Ingibjorg GunnarsdottirUnit for Nutrition Research, Landspitali, The National University Hospital of Iceland and Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland.
University of Iceland · ISIcelandic Heart Association · ISNational Institute on Aging · USVrije Universiteit Amsterdam · NLAmsterdam University Medical Centers · NLStatens Serum Institut · DKUniversity of York · GB

Funding

CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
NIA NIH HHS N01 AG012100NIH HHS N01-AG-12100
6 · The paper itself

Abstract

backgroundObesity has been longitudinally associated with depression but only few studies take a life course approach. This longitudinal study investigates whether being overweight or obese at age 8 and 13 years is associated with depressive symptoms more than 60 years later and whether this association is independent of late-life body mass index (BMI). We also investigated the association of being overweight/obese at age 8 or 13 years with ever having major depressive disorder (lifetime MDD).

methodThis analysis is based on a sub-sample of 889 AGES-Reykjavik participants with measured BMI data from early life. Late-life depressive symptoms were measured with the Geriatric Depression Scale (GDS) and lifetime MDD was assessed at late-life using the Mini International Neuropsychiatric Interview. Logistic regression analysis was used to estimate the relationships between BMI (continuous and categorical) at age 8 or 13 years, and late-life depressive symptoms (measured as GDS ≥ 5) or lifetime MDD, adjusted for sex, education, physical activity, smoking status and alcohol use. In a separate model, additional adjustments were made for late-life BMI.

resultsOne hundred and one subjects (11%) had depressive symptoms at late-life (GDS ≥ 5), and 39 subjects (4.4%) had lifetime MDD. Being overweight or obese at age 8 or 13 years was not associated with higher depressive symptoms during late-life, irrespective of late-life BMI. Being overweight or obese at age 8 years, but not age 13 years was associated with an increased risk of lifetime MDD (Odds Ratio (OR) (95% confidence interval [CI]) for age 8 = 4.03[1.16-13.96]P = 0.03 and age 13 = 2.65[0.69-10.26] P = 0.16, respectively).

conclusionBeing overweight in childhood was associated with increased odds of lifetime MDD, although the magnitude of the risk is uncertain given the small numbers of participants with lifetime MDD. No clear association was observed between childhood and adolescent overweight/obesity and late-life depressive symptoms irrespective of late life BMI.

Indexed as

Major Depressive DisorderPediatric ObesityAdolescentAgedBody Mass IndexChildDepressionHumansLongevityLongitudinal StudiesOverweightBody mass indexChildhood obesityDepressive symptomsLifetime major depressive disorder

Identifiers

PMID31964368
PMCPMC6971945
OpenAlexW3003787555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.