Evidence map›Paper›PMID 31964363›Full record

ArticleBMC infectious diseases2020

Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria.

Kari Otterdal, Aase Berg, Annika E Michelsen, Sam Patel, Ida Gregersen, Ellen Lund Sagen, Bente Halvorsen, Arne Yndestad, Thor Ueland, Nina Langeland and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. A population of CD4Clinical & translational immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Kari OtterdalResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway. kari.otterdal@rr-research.no.
Aase BergDepartment of Medicine, Stavanger University Hospital, PO Box 8100, 4068, Stavanger, Norway.
Annika E MichelsenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
Sam PatelDepartment of Medicine, Central Hospital of Maputo, 1100, Maputo, Mozambique.
Ida GregersenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
Ellen Lund SagenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
Bente HalvorsenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
Arne YndestadResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
Thor UelandResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
Nina LangelandDepartment of Clinical Science, University of Bergen, 5021, Bergen, Norway.
Pål AukrustResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, PO Box 4950, 0424, Oslo, Nydalen, Norway.
University of Oslo · NOOslo University Hospital · NOMaputo Central Hospital · MZStavanger University Hospital · NOUniversity of Bergen · NO

Funding

Helse Sør-Øst RHF 2015060Helse Vest Regionalt Helseføretak 911539
6 · The paper itself

Abstract

backgroundThe immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic cytokine exerting both inflammatory and anti-inflammatory effects, but data on IL-27 in malaria patients are scarce.

methodsClinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) HIV-1 co-infection, from HIV-infected patients with similar symptoms without malaria (n = 58) and from healthy controls (n = 52). In vitro studies were performed in endothelial cells and PBMC using hemozoin crystals. Samples were analyzed using enzyme immunoassays and quantitative PCR.

results(i) IL-27 was markedly up-regulated in malaria patients compared with controls and HIV-infected patients without malaria, showing no relation to HIV co-infection. (ii) IL-27 was correlated with P. falciparum parasitemia and von Willebrand factor as a marker of endothelial activation, but not with disease severity. (iii) In vitro, IL-27 modulated the hemozoin-mediated cytokine response in endothelial cells and PBMC with enhancing effects on IL-6 and attenuating effects on IL-8.

conclusionOur findings show that IL-27 is regulated during falciparum malaria, mediating both inflammatory and anti-inflammatory effects, potentially playing an immune-regulatory role during falciparum malaria.

Indexed as

HIV-1AdolescentAdultAgedAged, 80 and overAIDS-Related Opportunistic InfectionsCells, CulturedCoinfectionCross-Sectional StudiesEndothelial CellsFemaleHemeproteinsHumansInterleukinsLeukocytes, MononuclearMalaria, FalciparumHemeproteinshemozoinInterleukinsMYDGF protein, humanEndothelial cellsFalciparum malariaHemozoinHIVIL-27InterleukinsPBMC

Identifiers

PMID31964363
PMCPMC6974969
OpenAlexW3001518382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.