ArticleBMC cancer2020
The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.
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47 citing papers in PubMed, 72 citations in OpenAlex.
- The Differential Diagnostic Value of Radiomics Signatures Between Single-Nodule Pulmonary Metastases and Second Primary Lung Cancer in Patients with Colorectal Cancer.Technology in cancer research & treatmentTrial
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- Higher-order multiple primary cancers and persistent cross-site risk across human papillomavirus-related anatomical sites in the United States: a population-based Surveillance, Epidemiology, and End Results study.Preventive medicine reports · 2026Article
- Risk factors for second primary cancer in patients who survive breast cancer.NPJ breast cancer · 2026Article
- Distinct Second Primary Tumor Phenotypes in Oral Squamous Cell Carcinoma According to Exposure Status and Immune Background.Journal of clinical medicine · 2026Article
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- Genetic Association of Primary Lung Cancer With Urological Cancers: A Bidirectional Mendelian Randomization Study and SEER Database Validation.Cancer medicine · 2025Article
- Next-generation sequencing identifies the mutational signature of double primary and metastatic malignancies: A case report.Current urology · 2025Article
- Clinical characteristics and prognostic factors analysis of patients stricken with double primary breast and ovarian cancer based on the SEER database.Gland surgery · 2025Article
- Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors.Translational oncology · 2025Article
- Analyzing Secondary Cancer Risk: A Machine Learning Approach.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Role of medico-administrative database in the selection of the target population in colorectal cancer screening program.Therapeutic advances in gastroenterology · 2025Article
- Utilizing patient data: A tutorial on predicting second cancer with machine learning models.Cancer medicine · 2024Article
- Melanoma as Subsequent Primary Malignancy in Hematologic Cancer Survivors-A Literature Review.Journal of clinical medicine · 2024Review
- Incidence and Characteristics of Multiple Primary Cancers: A 20-Year Retrospective Study of a Single Cancer Center in Korea.Cancers · 2024Article
- Relative risk of second malignant neoplasms highest among young adult cancer patients - a population-based registry study in Finland.Acta oncologica (Stockholm, Sweden) · 2024Article
- A case of lung adenocarcinoma expressing carbonic anhydrase IX and cluster of differentiation 10 antigen combined with renal clear cell carcinoma.CytoJournal · 2024Article
- Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature.World journal of gastrointestinal surgery · 2023Article
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Corrections and comments
- Erratum issued
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore people than ever before are currently living with a diagnosis of cancer and the number of people concerned is likely to continue to rise. Cancer survivors are at risk of developing a second primary cancer (SPC). This study aims to investigate the risk of SPC in Switzerland.
methodsThe study cohort included all patients with a first primary cancer recorded in 9 Swiss population-based cancer registries 1981-2009 who had a minimum survival of 6 months, and a potential follow-up until the end of 2014. We calculated standardized incidence ratios (SIR) to estimate relative risks (RR) of SPC in cancer survivors compared with the cancer risk of the general population. SIR were stratified by type of first cancer, sex, age and period of first diagnosis, survival period and site of SPC.
resultsA total of 33,793 SPC were observed in 310,113 cancer patients. Both male (SIR 1.18, 95%CI 1.16-1.19) and female (SIR 1.20, 95%CI 1.18-1.22) cancer survivors had an elevated risk of developing a SPC. Risk estimates varied substantially according to type of first cancer and were highest in patients initially diagnosed with cancer of the oral cavity and pharynx, Hodgkin lymphoma, laryngeal, oesophageal, or lung cancer. Age-stratified analyses revealed a tendency towards higher RR in patients first diagnosed at younger ages. Stratified by survival period, risk estimates showed a rising trend with increasing time from the initial diagnosis. We observed strong associations between particular types of first and SPC, i.e. cancer types sharing common risk factors such as smoking or alcohol consumption (e.g. repeated cancer of the oral cavity and pharynx (SIR
conclusionSwiss cancer survivors have an increased risk of developing a SPC compared to the general population, particularly patients first diagnosed before age 50 and those surviving more than 10 years. Cancer patients should remain under continued surveillance not only for recurrent cancers but also for new cancers. Some first and SPCs share lifestyle associated risk factors making it important to promote healthier lifestyles in both the general population and cancer survivors.
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