ArticleBMC infectious diseases2020
Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Adverse events in neonates with congenital heart disease after cardiovascular surgery: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- A meta-analysis showing the effect of surgical site wound infections and associated risk factors in neonatal surgeries.International wound journal · 2022Pooled it
- Surgical-site infections in infants undergoing surgery for congenital heart disease during their first year of life.JTCVS open · 2026Article
- Prevalence and outcomes of postoperative infection among pediatric congenital heart disease patients in intensive care units: a single center retrospective study.BMC infectious diseases · 2026Article
- Risk Factors and Microbiological Characterization of Healthcare Associated Infection Post Cardiac Surgery Among Children in Beijing, China.Infection and drug resistance · 2026Article
- Evaluation of nosocomial infections after congenital heart surgery in children: a comprehensive analysis including the systemic immune-inflammation index.Frontiers in pediatrics · 2026Article
- Case Series of Bacteremia Associated with Probiotic Use in Children after Cardiac Surgery, China.Emerging infectious diseases · 2026Review
- Determinants of Early Mortality After Congenital Heart Surgery: A 7-Year Single-center Experience in Saudi Arabia.Journal of the Saudi Heart Association · 2026Article
- Incidence of bloodstream infection after open-heart surgery with delayed sternal closure among children with congenital heart disease: a single-center retrospective study.BMC research notes · 2025Observational
- Utility of procalcitonin in diagnosing early postoperative sepsis after pediatric cardiac surgery in Malaysia.Acute and critical care · 2025Article
- Impact of Polyhexanide Care Bundle on Surgical Site Infections in Paediatric and Neonatal Cardiac Surgery: A Propensity Score-Matched Retrospective Cohort Study.International wound journal · 2025Article
- Machine Learning Model for Predicting Risk Factors of Prolonged Length of Hospital Stay in Patients with Aortic Dissection: a Retrospective Clinical Study.Journal of cardiovascular translational research · 2025Article
- Risk factors for early secondary infections after cardiopulmonary bypass in children with congenital heart disease: a single-center analysis of 265 cases.Translational pediatrics · 2025Article
- Prevalence and contributing factors of nosocomial bloodstream infections in pediatric cardiac ICU patients at chamran hospital, Isfahan.ARYA atherosclerosis · 2025Article
- Nanobubble Ozone Stored in Hyaluronic Acid-Decorated Liposome Solutions: Inactivating Antibiotic-Resistant Bacteria and Genotoxicity, Sub-Acute and Sub-Chronic Toxicity Tests.Infection and drug resistance · 2025Article
- Nosocomial Infections After Pediatric Congenital Heart Disease Surgery: Data from National Center for Cardiovascular Diseases in China.Infection and drug resistance · 2024Article
- Predictors of Human Milk Feeding and Direct Breastfeeding for Infants with Single Ventricle Congenital Heart Disease: Machine Learning Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Registry.The Journal of pediatrics · 2023Article
- Prevention of catheter-related bloodstream infections in patients with extracorporeal membrane oxygenation: a literature review.Revista da Associacao Medica Brasileira (1992) · 2023Review
- Digital Online Anaesthesia Patient Informed Consent before Elective Diagnostic Procedures or Surgery: Recent Practice in Children-An Exploratory ESAIC Survey (2021).Journal of clinical medicine · 2022Article
- Analysis of the risk factors for severe lung injury after radical surgery for tetralogy of fallot.Frontiers in surgery · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe aim of our study was to analyze the risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease (CHD).
methodsWe performed a retrospective cohort study, and children with CHD who underwent open-heart surgeries at Shanghai Children's Medical Center from January 1, 2012 to December 31, 2018 were included. The baseline characteristics of these patients of different ages, including neonates (0-1 months old), infants (1-12 months old) and children (1-10 years old), were analyzed, and the association of risk factors with postoperative nosocomial infection were assessed.
resultsA total of 11,651 subjects were included in the study. The overall nosocomial infection rate was 10.8%. Nosocomial infection rates in neonates, infants, and children with congenital heart disease were 32.9, 15.4, and 5.2%, respectively. Multivariate logistic regression analysis found age (OR 0798, 95%CI: 0.769-0.829; P < 0.001), STS risk grade (OR 1.267, 95%CI: 1.159-1.385; P < 0.001), body mass index (BMI) <5th percentile (OR 1.295, 95%CI: 1.023-1.639; P = 0.032), BMI >95th percentile (OR 0.792, 95%CI: 0.647-0.969; P = 0.023), cardiopulmonary bypass (CPB) time (OR 1.008, 95%CI: 1.003-1.012; P < 0.001) and aortic clamping time (OR 1.009, 1.002-1.015; P = 0.008) were significantly associated with nosocomial infection in CHD infants. After adjusted for confounding factors, we found STS risk grade (OR 1.38, 95%CI: 1.167-1.633; P < 0.001), BMI < 5th percentile (OR 1.934, 95%CI: 1.377-2.715; P < 0.001), CPB time (OR 1.018, 95%CI: 1.015-1.022; P < 0.001), lymphocyte/WBC ratio<cut off value (OR 3.818, 95%CI: 1.529-9.533; P = 0.004) and AST>cut off value (OR 1.546, 95%CI: 1.119-2.136; P = 0.008) were significantly associated with nosocomial infection in CHD children.
conclusionOur study suggested STS risk grade, BMI, CPB duration, low lymphocyte/WBC or high neutrophil/WBC ratio were independently associated with nosocomial infection in CHD infant and children after cardiac surgery.
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