Evidence map›Paper›PMID 31964216›Full record

ArticleAutophagy2020

Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy.

Doo Sin Jo, So Jung Park, Ae-Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K Kim and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 63 citations in OpenAlex.

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  15. Article
  16. Mammalian pexophagy at a glance.Journal of cell science · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Doo Sin JoSchool of Life Sciences, Kyungpook National University , Daegu, Republic of Korea.
So Jung ParkDepartment of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge, UK.
Ae-Kyeong KimMetabolism & Neurophysiology Research Group, Korea Research Institute of Bioscience and Biotechnology , Daejeon, Republic of Korea.
Na Yeon ParkSchool of Life Sciences, Kyungpook National University , Daegu, Republic of Korea.
Joon Bum KimSchool of Life Sciences, Kyungpook National University , Daegu, Republic of Korea.
Ji-Eun BaeSchool of Life Sciences, Kyungpook National University , Daegu, Republic of Korea.
Hyun Jun ParkSchool of Life Sciences, Kyungpook National University , Daegu, Republic of Korea.
Ji Hyun ShinDepartment of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge, UK.
Jong Wook ChangCell and Regenerative Medicine Institute, Samsung Medical Center , Seoul, Republic of Korea.
Peter K KimDepartment of Biochemistry, University of Toronto , Toronto, ON, Canada.ORCID 0000-0001-6626-0575
Yong-Keun JungSchool of Biological Sciences, Seoul National University , Seoul, Republic of Korea.
Jae-Young KohDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Republic of Korea.
Seong-Kyu ChoeDepartment of Microbiology, Wonkwang University School of Medicine , Iksan, Jeonbuk, Republic of Korea.
Kyu-Sun LeeMetabolism & Neurophysiology Research Group, Korea Research Institute of Bioscience and Biotechnology , Daejeon, Republic of Korea.
Dong-Hyung ChoSchool of Life Sciences, Kyungpook National University , Daegu, Republic of Korea.ORCID 0000-0002-8859-0310
Kyungpook National University · KRKorea Research Institute of Bioscience and Biotechnology · KRUniversity of Cambridge · GBSamsung Medical Center · KRSeoul National University · KRUlsan College · KRUniversity of Toronto · CAWonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quality control of peroxisomes is essential for cellular homeostasis. However, the mechanism underlying pexophagy is largely unknown. In this study, we identified HSPA9 as a novel pexophagy regulator. Downregulation of HSPA9 increased macroautophagy/autophagy but decreased the number of peroxisomes

Indexed as

AutophagyHSP70 Heat-Shock ProteinsHumansMacroautophagyMitochondrial ProteinsPeroxisomesReactive Oxygen SpeciesHSP70 Heat-Shock ProteinsHSPA9 protein, humanMitochondrial ProteinsReactive Oxygen SpeciesDrosophilaHSPA9Parkinson diseaseperoxisomepexophagyROS

Identifiers

PMID31964216
PMCPMC7595578
OpenAlexW3002448802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.