Evidence map›Paper›PMID 31964160›Full record

SynthesisThe American journal of psychiatry2020

Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders.

Lisa M McTeague, Benjamin M Rosenberg, James W Lopez, David M Carreon, Julia Huemer, Ying Jiang, Christina F Chick, Simon B Eickhoff, Amit Etkin

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 23 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 23 syntheses or guidelines pooled it, 385 citations in OpenAlex.

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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lisa M McTeagueDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
Benjamin M RosenbergDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
James W LopezDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
David M CarreonDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
Julia HuemerDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
Ying JiangDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
Christina F ChickDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
Simon B EickhoffDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
Amit EtkinDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (McTeague, Lopez); Department of Psychology, University of California, Los Angeles (Rosenberg); Department of Psychiatry and Behavioral Sciences and Wu Tsai Neurosciences Institute, Stanford University, Stanford, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); Veterans Affairs Palo Alto Health Care System and the Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, Calif. (Carreon, Huemer, Jiang, Chick, Etkin); and Medical University of Vienna, Vienna, Institute for Neuroscience and Medicine (Brain and Behavior, INM-7), Research Center Jülich, Jülich, Germany, and Institute for Systems Neuroscience, School of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff).
VA Palo Alto Health Care System · US

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
A “Circuits-First” Platform for Personalized Neurostimulation TreatmentDP1MH116506 · NIMH · STANFORD UNIVERSITY · PI ETKIN, AMIT · 2017 to 2021
$5.2M
Remediating Emotion Deficits in PTSD: Probing and Modulating NeurocircuitsK23MH104849 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCTEAGUE, LISA M · 2014 to 2017
$746k
Meta-analysis in human brain mappingR56MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2020 to 2020
$543k
NIMH NIH HHS DP1 MH116506NIMH NIH HHS K23 MH104849NIMH NIH HHS R01 MH074457NIMH NIH HHS R56 MH074457
6 · The paper itself

Abstract

objectiveDisrupted emotional processing is a common feature of many psychiatric disorders. The authors investigated functional disruptions in neural circuitry underlying emotional processing across a range of tasks and across psychiatric disorders through a transdiagnostic quantitative meta-analysis of published neuroimaging data.

methodsA PubMed search was conducted for whole-brain functional neuroimaging findings published through May 2018 that compared activation during emotional processing tasks in patients with psychiatric disorders (including schizophrenia, bipolar or unipolar depression, anxiety, and substance use) to matched healthy control participants. Activation likelihood estimation (ALE) meta-analyses were conducted on peak voxel coordinates to identify spatial convergence.

resultsThe 298 experiments submitted to meta-analysis included 5,427 patients and 5,491 control participants. ALE across diagnoses and patterns of patient hyper- and hyporeactivity demonstrated abnormal activation in the amygdala, the hippocampal/parahippocampal gyri, the dorsomedial/pulvinar nuclei of the thalamus, and the fusiform gyri, as well as the medial and lateral dorsal and ventral prefrontal regions. ALE across disorders but considering directionality demonstrated patient hyperactivation in the amygdala and the hippocampal/parahippocampal gyri. Hypoactivation was found in the medial and lateral prefrontal regions, most pronounced during processing of unpleasant stimuli. More refined disorder-specific analyses suggested that these overall patterns were shared to varying degrees, with notable differences in patterns of hyper- and hypoactivation.

conclusionsThese findings demonstrate a pattern of neurocircuit disruption across major psychiatric disorders in regions and networks key to adaptive emotional reactivity and regulation. More specifically, disruption corresponded prominently to the "salience" network, the ventral striatal/ventromedial prefrontal "reward" network, and the lateral orbitofrontal "nonreward" network. Consistent with the Research Domain Criteria initiative, these findings suggest that psychiatric illness may be productively formulated as dysfunction in transdiagnostic neurobehavioral phenotypes such as neurocircuit activation.

Indexed as

EmotionsNeural PathwaysAdolescentAdultAgedChildFemaleFunctional NeuroimagingHumansLikelihood FunctionsMaleMental DisordersMiddle AgedYoung AdultfMRIMeta-AnalysisNeuroanatomyNeuroimagingRDoCTransdiagnostic

Identifiers

PMID31964160
PMCPMC7280468
OpenAlexW3001336471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.