ArticleLife (Basel, Switzerland)2020
Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry.
Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Hydroxy acid conjugation to lipids increases structural and hydrolytic stability.Nature communications · 2026Article
- Probing the Limits of Reactant Concentration and Volume in Primitive Polyphenyllactate Synthesis and Microdroplet Assembly Processes.ACS bio & med chem Au · 2025Article
- Alternative Pathways in Astrobiology: Reviewing and Synthesizing Contingency and Non-Biomolecular Origins of Terrestrial and Extraterrestrial Life.Life (Basel, Switzerland) · 2024Review
- Solvent constraints for biopolymer folding and evolution in extraterrestrial environments.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Primitive membraneless compartments as a window into the earliest cells.Biophysical reviews · 2023Article
- Recent progress in primitive polyester synthesis and membraneless microdroplet assembly.Biophysics and physicobiology · 2023Article
- Geoelectrochemistry-driven alteration of amino acids to derivative organics in carbonaceous chondrite parent bodies.Nature communications · 2022Article
- Spontaneous Formation of Functional Structures in Messy Environments.Life (Basel, Switzerland) · 2022Article
- Sequencing the origins of life.BBA advances · 2022Review
- Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution.Life (Basel, Switzerland) · 2021Review
- Increasing complexity of primitive compartments.Biophysics and physicobiology · 2021Article
- Connecting primitive phase separation to biotechnology, synthetic biology, and engineering.Journal of biosciences · 2021Review
- Prebiotic oligomerization and self-assembly of structurally diverse xenobiological monomers.Scientific reports · 2020Article
- Universal Codons with Enrichment from GC to AU Nucleotide Composition Reveal a Chronological Assignment from Early to Late Along with LUCA Formation.Life (Basel, Switzerland) · 2020Article
- The Future of Origin of Life Research: Bridging Decades-Old Divisions.Life (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A variety of organic chemicals were likely available on prebiotic Earth. These derived from diverse processes including atmospheric and geochemical synthesis and extraterrestrial input, and were delivered to environments including oceans, lakes, and subaerial hot springs. Prebiotic chemistry generates both molecules used by modern organisms, such as proteinaceous amino acids, as well as many molecule types not used in biochemistry. As prebiotic chemical diversity was likely high, and the core of biochemistry uses a rather small set of common building blocks, the majority of prebiotically available organic compounds may not have been those used in modern biochemistry. Chemical evolution was unlikely to have been able to discriminate which molecules would eventually be used in biology, and instead, interactions among compounds were governed simply by abundance and chemical reactivity. Previous work has shown that likely prebiotically available α-hydroxy acids can combinatorially polymerize into polyesters that self-assemble to create new phases which are able to compartmentalize other molecule types. The unexpectedly rich complexity of hydroxy acid chemistry and the likely enormous structural diversity of prebiotic organic chemistry suggests chemical evolution could have been heavily influenced by molecules not used in contemporary biochemistry, and that there is a considerable amount of prebiotic chemistry which remains unexplored.
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