Evidence map›Paper›PMID 31963860›Full record

ReviewMolecules (Basel, Switzerland)2020

The Pictet-Spengler Reaction Updates Its Habits.

Andrea Calcaterra, Laura Mangiardi, Giuliano Delle Monache, Deborah Quaglio, Silvia Balducci, Simone Berardozzi, Antonia Iazzetti, Roberta Franzini, Bruno Botta, Francesca Ghirga

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Synthesis of tetrahydrofuro[3,2-Beilstein journal of organic chemistry · 2023
    Article
  11. Article
  12. Article
  13. Highly Stereoselective Ugi/Pictet-Spengler Sequence.The Journal of organic chemistry · 2022
    Article
  14. Article
  15. Enzymatic Late-Stage Modifications: Better Late Than Never.Angewandte Chemie (International ed. in English) · 2021
    Review
  16. Enzymkatalysierte späte Modifizierungen: Besser spät als nie.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea CalcaterraDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-7036-6620
Laura MangiardiDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-9937-4365
Giuliano Delle MonacheDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Deborah QuaglioDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Silvia BalducciDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Simone BerardozziDepartment of Chemistry and Applied Biosciences, ETH-Zürich, Vladimir-Prelog Weg 4, 8093 Zürich, Switzerland.ORCID 0000-0002-3352-9811
Antonia IazzettiDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-7792-774X
Roberta FranziniDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Bruno BottaDepartment of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8707-4333
Francesca GhirgaCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

Funding

European Cooperation in Science and Technology ESF COST Action CM1407Ministero dell'Istruzione, dell'Università e della Ricerca ARS01_00432Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza - L.232/2016Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2017Sapienza Università di Roma Progetto grande di ricerca di Ateneo 2017
6 · The paper itself

Abstract

The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic frameworks. In the

Indexed as

Models, MolecularAlkaloidsBiological ProductsCyclizationRutheniumAlkaloidsBiological ProductsRutheniumalkaloidcascade reactionmulticomponent reactionnatural productsPictet-Spenglertetrahydroisoquinolinetetrahydro-β-carbolineTHBCTHIQtotal synthesis

Identifiers

PMID31963860
PMCPMC7024544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.