Evidence map›Paper›PMID 31963815›Full record

ArticleCells2020

Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury.

Judith Sommer, Christoph Dorn, Erwin Gäbele, Frauke Bataille, Kim Freese, Tatjana Seitz, Wolfgang E Thasler, Reinhard Büttner, Ralf Weiskirchen, Anja Bosserhoff and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Judith SommerInstitute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.
Christoph DornInstitute of Pharmacy, University Regensburg, D-93053 Regensburg, Germany.ORCID 0000-0002-2560-9598
Erwin GäbeleDepartment of Internal Medicine I, University Hospital Regensburg, D-93053 Regensburg, Germany.
Frauke BatailleInstitute of Pathology, University Regensburg, D-93049 Regensburg, Germany.
Kim FreeseInstitute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.
Tatjana SeitzInstitute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.
Wolfgang E ThaslerHepacult GmbH, D-82152 Planegg/Martinsried, Germany.
Reinhard BüttnerInstitute of Pathology, University Hospital Cologne, D-50937 Cologne, Germany.
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, D-52074 Aachen, Germany.ORCID 0000-0003-3888-0931
Anja BosserhoffInstitute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.ORCID 0000-0001-8147-394X
Claus HellerbrandInstitute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Fahrstr. 17, D-91054 Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Regensburg · DEUniversitätsklinikum Aachen · DEUniversity Hospital Cologne · DEUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and cell context-specific manner. In this study, we aimed to gain insight into the function of FHL2 in cholestatic liver injury. FHL2 expression was significantly increased in the bile duct ligation (BDL) model in mice. In

Indexed as

AnimalsBile Acids and SaltsBile DuctsCholestasisDisease Models, AnimalGene Expression RegulationHepatic Stellate CellsHep G2 CellsHumansInflammationLigationLIM-Homeodomain ProteinsLiverLiver CirrhosisMaleMice, KnockoutBile Acids and SaltsFHL2 protein, humanFhl2 protein, mouseLIM-Homeodomain ProteinsMuscle ProteinsTranscription Factorsbile acidscholestatic liver injuryFHL2four-and-a-half LIM-domain protein 2

Identifiers

PMID31963815
PMCPMC7016690
OpenAlexW3000653646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.