Evidence map›Paper›PMID 31963802›Full record

Trial reportNutrients2020

Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption.

Melynda S Coker, Kaylee R Ladd, Jimin Kim, Carl J Murphy, Ryan DeCort, Bradley R Newcomer, Robert R Wolfe, Robert H Coker

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Melynda S CokerDepartment of Natural Resources and Environment, University of Alaska Fairbanks, 505 South Chandalar Drive, Fairbanks, AK 99775, USA.ORCID 0000-0002-9019-6216
Kaylee R LaddDepartment of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK 99775, USA.
Jimin KimDepartment of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK 99775, USA.ORCID 0000-0002-4729-5892
Carl J MurphyInstitute of Arctic Biology, Department of Chemistry & Biochemistry, University of Alaska Fairbanks1930 Yukon Dr. Room 136, Fairbanks, AK 99775, USA.
Ryan DeCortBassett Army Community Hospital, 4076 Neely Road, FortWainwright, United States Army, Fairbanks, AK 99703, USA.
Bradley R NewcomerHonors College, 1501 251Warren Service Drive, Room 105, James Madison University, Harrisonburg, VA 22807, USA.ORCID 0000-0002-8268-1721
Robert R WolfeDepartment of Geriatrics, Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, 4301 West Markham, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Robert H CokerDepartment of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK 99775, USA.ORCID 0000-0002-1037-9339
University of Alaska Fairbanks · USInstitute on Aging · USJames Madison University · USUnited States Army · US

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
Biomedical Learning and Student Training (BLaST) ProgramUL1GM118991 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI HUEFFER, KARSTEN · 2015 to 2023
$19.0M
Renovation of LARS for Arctic Ground Squirrel BreedingP20GM130443 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI KELLY L DREW · 2019 to 2026
$16.4M
Biomedical Learning and Student Training (BLaST) ProgramRL5GM118990 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI HUEFFER, KARSTEN, REYNOLDS, ARLEIGH JAMES · 2015 to 2023
$10.5M
Biomedical Learning and Student Training (BLaST) ProgramTL4GM118992 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI HUEFFER, KARSTEN, REYNOLDS, ARLEIGH JAMES · 2015 to 2023
$7.1M
NIGMS NIH HHS P20 GM103395NIGMS NIH HHS P20 GM130443NIGMS NIH HHS RL5 GM118990NIGMS NIH HHS TL4 GM118992NIGMS NIH HHS UL1 GM118991NIH HHS P20GM103395NIH HHS UL1GM118991
6 · The paper itself

Abstract

Excess alcohol consumption is a top risk factor for death and disability. Fatty liver will likely develop and the risk of liver disease increases. We have previously demonstrated that an essential amino acid supplement (EAAS) improved protein synthesis and reduced intrahepatic lipid in the elderly. The purpose of this exploratory pilot study was to initiate the evaluation of EAAS on intrahepatic lipid (IHL), body composition, and blood lipids in individuals with mild to moderate alcohol use disorder (AUD). Following consent, determination of eligibility, and medical screening, 25 participants (18 males at 38 ± 15 years/age and 7 females at 34 ± 18 years/age) were enrolled and randomly assigned to one of two dosages: a low dose (LD: 8 g of EAAS twice/day (BID)) or high dose (HD: 13 g of EAAS BID). Five of the twenty-five enrolled participants dropped out of the intervention. Both groups consumed the supplement BID for 4 weeks. Pre- and post-EAAS administration, IHL was determined using magnetic resonance imaging/spectroscopy, body composition was analyzed using dual-energy X-ray absorptiometry, and blood parameters were measured by LabCorp. T-tests were used for statistical analysis and considered significant at

Indexed as

Dietary SupplementsAdultAlaskaAlcohol DrinkingAmino Acids, EssentialBiomarkersBody CompositionFatty Liver, AlcoholicFemaleHumansLipidsLiverMaleMiddle AgedPilot ProjectsTime FactorsAmino Acids, EssentialBiomarkersLipidsalcoholamino acidsliver

Identifiers

PMID31963802
PMCPMC7019240
OpenAlexW2995330719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.