Evidence map›Paper›PMID 31963741›Full record

ReviewViruses2020

Microtubules in Polyomavirus Infection.

Lenka Horníková, Kateřina Bruštíková, Jitka Forstová

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Nuclear Cytoskeleton in Virus Infection.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lenka HorníkováDepartment of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 25250 Postal code Vestec, Czech Republic.
Kateřina BruštíkováDepartment of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 25250 Postal code Vestec, Czech Republic.
Jitka ForstováDepartment of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 25250 Postal code Vestec, Czech Republic.
Charles University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microtubules, part of the cytoskeleton, are indispensable for intracellular movement, cell division, and maintaining cell shape and polarity. In addition, microtubules play an important role in viral infection. In this review, we summarize the role of the microtubules' network during polyomavirus infection. Polyomaviruses usurp microtubules and their motors to travel via early and late acidic endosomes to the endoplasmic reticulum. As shown for SV40, kinesin-1 and microtubules are engaged in the release of partially disassembled virus from the endoplasmic reticulum to the cytosol, and dynein apparently assists in the further disassembly of virions prior to their translocation to the cell nucleus-the place of their replication. Polyomavirus gene products affect the regulation of microtubule dynamics. Early T antigens destabilize microtubules and cause aberrant mitosis. The role of these activities in tumorigenesis has been documented

Indexed as

Host-Pathogen InteractionsAnimalsCapsid ProteinsCell NucleusCytosolEndoplasmic ReticulumEndosomesHumansMiceMicrotubulesPolyomavirusProtein BindingVirus ReplicationCapsid ProteinsVP1 protein, polyomaviruscell cycle blockdyneinkinesinmicrotubulesmolecular motorspolyomavirusT antigensvirusvirus traffickingVP1 capsid protein

Identifiers

PMID31963741
PMCPMC7019765
OpenAlexW3000059927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.