Evidence map›Paper›PMID 31963736›Full record

ArticleBiomolecules2020

A Combined Proteomics, Metabolomics and In Vivo Analysis Approach for the Characterization of Probiotics in Large-Scale Production.

Laura Bianchi, Luca Laghi, Virginia Correani, Emily Schifano, Claudia Landi, Daniela Uccelletti, Benedetta Mattei

Abstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. A comprehensive approach, based on the use ofCurrent research in food science · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Microorganisms · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura BianchiFunctional Proteomics Laboratory, Department of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-9219-1227
Luca LaghiDepartment of Agro-Food Science and Technology, University of Bologna, 40126 Cesena, Italy.ORCID 0000-0003-1593-7376
Virginia CorreaniDepartment of Biochemical Sciences, Sapienza University, 00185 Roma, Italy.
Emily SchifanoDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, 00185 Rome, Italy.
Claudia LandiFunctional Proteomics Laboratory, Department of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0410-8038
Daniela UccellettiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, 00185 Rome, Italy.ORCID 0000-0001-6841-8129
Benedetta MatteiDepartment MESVA, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0003-2927-6329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The manufacturing processes of commercial probiotic strains may be affected in different ways in the attempt to optimize yield, costs, functionality, or stability, influencing gene expression, protein patterns, or metabolic output. Aim of this work is to compare different samples of a high concentration (450 billion bacteria) multispecies (8 strains) formulation produced at two different manufacturing sites, United States of America (US) and Italy (IT), by applying a combination of functional proteomics, metabolomics, and in vivo analyses. Several protein-profile differences were detected between IT- and US-made products, with

Indexed as

AgingAnimalsBacterial ProteinsBifidobacteriumCaenorhabditis elegansDietary SupplementsLactobacillusLongevityMetabolomicsProbioticsProteomicsStreptococcus thermophilusBacterial ProteinsagingCaenorhabditis elegansfunctional proteomicsmetabolomicsoxidative stressprobiotic quality assessment

Identifiers

PMID31963736
PMCPMC7022454

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.