Evidence map›Paper›PMID 31963716›Full record

ArticleInternational journal of molecular sciences2020

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D

Magdalena Milczarek, Michał Chodyński, Anita Pietraszek, Martyna Stachowicz-Suhs, Kaori Yasuda, Toshiyuki Sakaki, Joanna Wietrzyk, Andrzej Kutner

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Structure and the Anticancer Activity of Vitamin D Receptor Agonists.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Magdalena MilczarekHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla, 53-114 Wroclaw, Poland.ORCID 0000-0001-6696-5305
Michał ChodyńskiDepartment of Chemistry, Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warsaw, Poland.ORCID 0000-0002-6950-6515
Anita PietraszekDepartment of Chemistry, Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Martyna Stachowicz-SuhsHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla, 53-114 Wroclaw, Poland.ORCID 0000-0003-0170-9436
Kaori YasudaDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Toshiyuki SakakiDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Joanna WietrzykHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla, 53-114 Wroclaw, Poland.ORCID 0000-0003-4980-6606
Andrzej KutnerDepartment of Bioanalysis and Drug Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.ORCID 0000-0002-9518-4142
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLInstytut Farmaceutyczny · PLToyama Prefectural University · JPMedical University of Warsaw · PL

Funding

National Science Center (Poland) DEC-2012/05/N/NZ5/00883
6 · The paper itself

Abstract

Experimental data indicate that low-calcemic vitamin D derivatives (VDDs) exhibit anticancer properties, both

Indexed as

Antineoplastic AgentsCell ProliferationCell SurvivalColorectal NeoplasmsDrug SynergismEpithelial-Mesenchymal TransitionErgocalciferolsFluorouracilGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansMolecular StructureSignal TransductionVitamin DVitamin D3 24-Hydroxylase1,25-dihydroxyvitamin DAntineoplastic AgentsCYP24A1 protein, humanErgocalciferolsFluorouracilVitamin DVitamin D3 24-Hydroxylase1,25-dihydroxyergocalciferol analogsantiproliferative activity in vitroCYP24A1-dependent metabolismdouble-point modified vitamin D2 analogshuman colorectal cancer cell linesvitamin D derivatives

Identifiers

PMID31963716
PMCPMC7013581
OpenAlexW2999818340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.