Evidence map›Paper›PMID 31963541›Full record

ArticleInternational journal of molecular sciences2020

Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis.

Yu-Ting Kang, Wen-Cheng Hsu, Chu-Chyn Ou, Hui-Chun Tai, Hui-Ting Hsu, Kun-Tu Yeh, Jiunn-Liang Ko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yu-Ting KangInstitute of Medicine, Chung-Shan Medical University, Taichung 402, Taiwan.ORCID 0000-0003-1355-9949
Wen-Cheng HsuDepartment of Endocrinology and Metabolism, Tungs' Taichung Metro Harbor Hospital, Taichung 435, Taiwan.
Chu-Chyn OuSchool of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan.
Hui-Chun TaiDepartment of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.
Hui-Ting HsuDepartment of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.
Kun-Tu YehDepartment of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.ORCID 0000-0003-0665-8586
Jiunn-Liang KoInstitute of Medicine, Chung-Shan Medical University, Taichung 402, Taiwan.
Changhua Christian Hospital · TWChung Shan Medical University · TWChung Shan Medical University Hospital · TWTungs' Taichung MetroHarbor Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 105-2320-B-040-014-MY3Ministry of Science and Technology, Taiwan MOST 108-2320-B-040 -015 -MY
6 · The paper itself

Abstract

Nickel (Ni), which is a carcinogenic workplace hazard, increases the risk of lung cancer. Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine that is involved in both angiogenesis and metastasis, but its role in lung cancer is still not clear. In this study, we assessed the role of ANGPTL4 in lung carcinogenesis under nickel exposure and investigated the effects of the antidiabetic drug metformin on ANGPTL4 expression and lung cancer chemoprevention. Our results showed that ANGPTL4 is increased in NiCl

Indexed as

Angiopoietin-Like Protein 4ApoptosisBiomarkers, TumorCell ProliferationCell Transformation, NeoplasticGene Expression Regulation, NeoplasticHumansHypoglycemic AgentsHypoxia-Inducible Factor 1, alpha SubunitLung NeoplasmsMetforminNeovascularization, PathologicNickelTrace ElementsTumor Cells, CulturedAngiopoietin-Like Protein 4ANGPTL4 protein, humanBiomarkers, TumorHIF1A protein, humanHypoglycemic AgentsHypoxia-Inducible Factor 1, alpha SubunitMetforminNickelTrace Elementsangiopoietin-like protein 4chemopreventionhypoxia-inducible factor 1 alphametforminNickel

Identifiers

PMID31963541
PMCPMC7014330
OpenAlexW2999491023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.