Evidence map›Paper›PMID 31963517›Full record

ArticleViruses2020

Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns.

Sten Calvelage, Marcin Smreczak, Anna Orłowska, Conrad Martin Freuling, Thomas Müller, Christine Fehlner-Gardiner, Susan Nadin-Davis, Dirk Höper, Paweł Trębas

Abstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Vaccine-induced Rabies in a Red Fox in Poland.Journal of veterinary research · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sten CalvelageInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0001-8511-9067
Marcin SmreczakDepartment of Virology, National Veterinary Research Institute, 24-100 Puławy, Poland.
Anna OrłowskaDepartment of Virology, National Veterinary Research Institute, 24-100 Puławy, Poland.ORCID 0000-0002-5781-115X
Conrad Martin FreulingInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, WHO Collaborating Centre for Rabies Surveillance and Research, OIE Reference Laboratory for Rabies, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0002-1076-398X
Thomas MüllerInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, WHO Collaborating Centre for Rabies Surveillance and Research, OIE Reference Laboratory for Rabies, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0002-0959-3653
Christine Fehlner-GardinerNational Reference Centre for Rabies, Ottawa Laboratory-Fallowfield, Canadian Food Inspection Agency, Ottawa, ON K2H 8P91, Canada.
Susan Nadin-DavisNational Reference Centre for Rabies, Ottawa Laboratory-Fallowfield, Canadian Food Inspection Agency, Ottawa, ON K2H 8P91, Canada.
Dirk HöperInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0001-8408-2274
Paweł TrębasDepartment of Virology, National Veterinary Research Institute, 24-100 Puławy, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rabies in wildlife has been successfully controlled in parts of Europe and North America using oral rabies vaccination, i.e., the distribution of baits containing live-attenuated virus strains. Occasionally, these vaccines caused vaccine virus-induced rabies cases. To elucidate the mechanisms of genetic selection and the effect of viral populations on these rabies cases, a next generation sequencing approach as well as comprehensive data analyses of the genetic diversity of Street Alabama Dufferin (SAD) and ERA vaccine virus strains and vaccine-induced rabies cases from Canada and several European countries were conducted. As a result, twelve newly generated sets of sequencing data from Canada and Poland were added to a pool of previously investigated samples. While the population-based analysis showed a segregation of viruses of ERA vaccine-induced rabies cases from those of SAD Bern original (SAD Bern

Indexed as

Genetic VariationGenome, ViralAnimalsAnimals, WildBrainCanadaEuropeHaplotypesHigh-Throughput Nucleotide SequencingRabiesRabies VaccinesRabies virusRNA, ViralSelection, GeneticRabies VaccinesRNA, Viralnext generation sequencingpopulation analysisrabiesvaccine

Identifiers

PMID31963517
PMCPMC7020022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.