Evidence map›Paper›PMID 31963369›Full record

ArticleCells2020

Natural Heart Regeneration in a Neonatal Rat Myocardial Infarction Model.

Hanjay Wang, Michael J Paulsen, Camille E Hironaka, Hye Sook Shin, Justin M Farry, Akshara D Thakore, Jinsuh Jung, Haley J Lucian, Anahita Eskandari, Shreya Anilkumar and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

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  10. Animal models to study cardiac regeneration.Nature reviews. Cardiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Michael J PaulsenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Camille E HironakaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Hye Sook ShinDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Justin M FarryDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Akshara D ThakoreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Jinsuh JungDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Haley J LucianDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Anahita EskandariDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Shreya AnilkumarDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Matthew A WuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Mariana C CabatuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Amanda N SteeleDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Lyndsay M StapletonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Stanford University · USCardiovascular Institute of the South · US

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
NHLBI NIH HHS R01 HL089315
6 · The paper itself

Abstract

Newborn mice and piglets exhibit natural heart regeneration after myocardial infarction (MI). Discovering other mammals with this ability would provide evidence that neonatal cardiac regeneration after MI may be a conserved phenotype, which if activated in adults could open new options for treating ischemic cardiomyopathy in humans. Here, we hypothesized that newborn rats undergo natural heart regeneration after MI. Using a neonatal rat MI model, we performed left anterior descending coronary artery ligation or sham surgery in one-day-old rats under hypothermic circulatory arrest (n = 74). Operative survival was 97.3%. At 1 day post-surgery, rats in the MI group exhibited significantly reduced ejection fraction (EF) compared to shams (87.1% vs. 53.0%,

Indexed as

RegenerationAnimalsAnimals, NewbornAurora Kinase BCell ProliferationCicatrixCollagenDisease Models, AnimalElectrocardiographyFemaleFibrosisKi-67 AntigenLigationMaleMyocardial InfarctionMyocytes, CardiacAurora Kinase BCollagenKi-67 AntigenTroponinheartmyocardial infarctionneonateregeneration

Identifiers

PMID31963369
PMCPMC7017245
OpenAlexW2999092318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.