ArticleMaterials (Basel, Switzerland)2020
Engineering Gels with Time-Evolving Viscoelasticity.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds.Biomaterials and biosystems · 2025Article
- Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity.Gels (Basel, Switzerland) · 2023Review
- Characterizing and Engineering Biomimetic Materials for Viscoelastic Mechanotransduction Studies.Tissue engineering. Part B, Reviews · 2022Review
- Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities.Polymers · 2022Review
- "Viscotaxis"- directed migration of mesenchymal stem cells in response to loss modulus gradient.Acta biomaterialia · 2021Article
- Article
- Engineering and Monitoring 3D Cell Constructs with Time-Evolving Viscoelasticity for the Study of Liver Fibrosis In Vitro.Bioengineering (Basel, Switzerland) · 2021Article
- Indentation probe with optical fibre array-based optical coherence tomography for material deformation.Journal of microscopy · 2021Article
- Determination by Relaxation Tests of the Mechanical Properties of Soft Polyacrylamide Gels Made for Mechanobiology Studies.Polymers · 2021Article
- Bioprinting of Collagen Type I and IIFrontiers in bioengineering and biotechnology · 2021Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective.Bioengineering (Basel, Switzerland) · 2020Review
- Preparation and Evaluation of New Glycopeptides Obtained by Proteolysis from Corn Gluten Meal Followed by Transglutaminase-Induced Glycosylation with Glucosamine.Foods (Basel, Switzerland) · 2020Article
- Multi-Functionalized Self-Assembling Peptides as Reproducible 3D Cell Culture Systems Enabling Differentiation and Survival of Various Human Neural Stem Cell Lines.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From a mechanical point of view, a native extracellular matrix (ECM) is viscoelastic. It also possesses time-evolving or dynamic behaviour, since pathophysiological processes such as ageing alter their mechanical properties over time. On the other hand, biomaterial research on mechanobiology has focused mainly on the development of substrates with varying stiffness, with a few recent contributions on time- or space-dependent substrate mechanics. This work reports on a new method for engineering dynamic viscoelastic substrates, i.e., substrates in which viscoelastic parameters can change or evolve with time, providing a tool for investigating cell response to the mechanical microenvironment. In particular, a two-step (chemical and enzymatic) crosslinking strategy was implemented to modulate the viscoelastic properties of gelatin hydrogels. First, gels with different glutaraldehyde concentrations were developed to mimic a wide range of soft tissue viscoelastic behaviours. Then their mechanical behaviour was modulated over time using microbial transglutaminase. Typically, enzymatically induced mechanical alterations occurred within the first 24 h of reaction and then the characteristic time constant decreased although the elastic properties were maintained almost constant for up to seven days. Preliminary cell culture tests showed that cells adhered to the gels, and their viability was similar to that of controls. Thus, the strategy proposed in this work is suitable for studying cell response and adaptation to temporal variations of substrate mechanics during culture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.