Evidence map›Paper›PMID 31963294›Full record

ArticleCancers2020

Gene Expression Analysis of Aggressive Clinical T1 Stage Clear Cell Renal Cell Carcinoma for Identifying Potential Diagnostic and Prognostic Biomarkers.

Jee Soo Park, Phillip M Pierorazio, Ji Hyun Lee, Hyo Jung Lee, Young Soun Lim, Won Sik Jang, Jongchan Kim, Seung Hwan Lee, Koon Ho Rha, Nam Hoon Cho and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03694912 (Development and Evaluation of High Risk Group Prediction Model in T1 Stage Renal Cell Cancer Using Molecular Biomarkers), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03694912 unknown statusnot on this map

Development and Evaluation of High Risk Group Prediction Model in T1 Stage Renal Cell Cancer Using Molecular Biomarkers

TypeobservationalSponsorYonsei UniversityRan2018 to 2023Enrolled426ConditionsClear Renal Cell Cancer (< 7cm Size)ArmsPartial or radical nephrectomy
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  9. Combining UBR5 and CD163Cancer immunology, immunotherapy : CII · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jee Soo ParkDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Phillip M PierorazioThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Park 213, Baltimore, MD 21287, USA.ORCID 0000-0003-0766-9981
Ji Hyun LeeDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Hyo Jung LeeDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Young Soun LimDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Won Sik JangDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0002-9082-0381
Jongchan KimDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Seung Hwan LeeDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Koon Ho RhaDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Nam Hoon ChoDepartment of Pathology, Yonsei University College of Medicine, Seoul 03722, Korea.
Won Sik HamDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0003-2246-8838
Yonsei University · KRJohns Hopkins University · USKyung Hee University · KR

Funding

Ministry of Health & Welfare, Republic of Korea HI17C1095
6 · The paper itself

Abstract

The molecular characteristics of early-stage clear cell renal cell carcinomas (ccRCCs) measuring ≤7 cm associated with poor clinical outcomes remain poorly understood. Here, we sought to validate genes associated with ccRCC progression and identify candidate genes to predict ccRCC aggressiveness. From among 1069 nephrectomies performed on patients, RNA sequencing was performed for 12 ccRCC patients with aggressive characteristics and matched pairs of 12 ccRCC patients without aggressive characteristics. Using a prospective cohort (ClinicalTrials.gov Identifier: NCT03694912), the expression levels of nine genes (

Indexed as

clear cell renal cell carcinomasgene expression analysisprognostic biomarkersRNA sequencing

Identifiers

PMID31963294
PMCPMC7017065
OpenAlexW3000020842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.