ArticleSensors (Basel, Switzerland)2020
Multiplexed Remote SPR Detection of Biological Interactions through Optical Fiber Bundles.
Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Surface plasmon resonance biosensors: Advancements, applications, and future directions in molecular detection.Biotechnology notes (Amsterdam, Netherlands) · 2026Review
- Double-layer optical fiber interferometer with bio-layer-modified reflector for label-free biosensing of inflammatory proteins.Scientific reports · 2024Article
- Rapid prototyping of a polymer MEMS droplet dispenser by laser-assisted 3D printing.Microsystems & nanoengineering · 2023Article
- A review of Optical Point-of-Care devices to Estimate the Technology Transfer of These Cutting-Edge Technologies.Biosensors · 2022Review
- Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders.Sensors (Basel, Switzerland) · 2022Review
- Immunosensing Based on Optical Fiber Technology: Recent Advances.Biosensors · 2021Review
- An Overview of Artificial Olfaction Systems with a Focus on Surface Plasmon Resonance for the Analysis of Volatile Organic Compounds.Biosensors · 2021Review
- A Highly Sensitive Refractive Index Sensor Based on a V-Shaped Photonic Crystal Fiber with a High Refractive Index Range.Sensors (Basel, Switzerland) · 2021Article
- Film-Thickness-Controllable System for Preparing Silver Nanofilms through Absorbance Monitoring of the Thickness during a Silver-Mirror Reaction.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
The development of sensitive methods for in situ detection of biomarkers is a real challenge to bring medical diagnosis a step forward. The proof-of-concept of a remote multiplexed biomolecular interaction detection through a plasmonic optical fiber bundle is demonstrated here. The strategy relies on a fiber optic biosensor designed from a 300 µm diameter bundle composed of 6000 individual optical fibers. When appropriately etched and metallized, each optical fiber exhibits specific plasmonic properties. The surface plasmon resonance phenomenon occurring at the surface of each fiber enables to measure biomolecular interactions, through the changes of the retro-reflected light intensity due to light/plasmon coupling variations. The functionalization of the microstructured bundle by multiple protein probes was performed using new polymeric 3D-printed microcantilevers. Such soft cantilevers allow for immobilizing the probes in micro spots, without damaging the optical microstructures nor the gold layer. We show here the potential of this device to perform the multiplexed detection of two different antibodies with limits of detection down to a few tenths of nanomoles per liter. This tool, adapted for multiparametric, real-time, and label free monitoring is minimally invasive and could then provide a useful platform for in vivo targeted molecular analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.