Evidence map›Paper›PMID 31963234›Full record

ArticleVaccines2020

Surface Immunogenic Protein of

Diego A Diaz-Dinamarca, Ricardo A Manzo, Daniel A Soto, María José Avendaño-Valenzuela, Diego N Bastias, Paulina I Soto, Daniel F Escobar, Valeria Vasquez-Saez, Flavio Carrión, Magdalena S Pizarro-Ortega and 4 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Frontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. A CRISPRi library screen in group BInfection and immunity · 2025
    Article
  9. A CRISPRi Library Screen in Group BbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Mucosal Vaccination withVaccines · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Diego A Diaz-DinamarcaSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.ORCID 0000-0001-5677-920X
Ricardo A ManzoSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
Daniel A SotoSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
María José Avendaño-ValenzuelaSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
Diego N BastiasSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
Paulina I SotoSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
Daniel F EscobarSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
Valeria Vasquez-SaezSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.
Flavio CarriónPrograma de Inmunología Traslacional, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 8320000, Chile.
Magdalena S Pizarro-OrtegaMillenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.
Christian A M WilsonDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8320000, Chile.ORCID 0000-0002-6499-6957
Julio BerriosEscuela de Ingeniería en Bioquímica, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0002-6180-0023
Alexis M KalergisMillenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.
Abel E VasquezSeccion de Biotecnologia, Instituto de Salud Publica de Chile, Santiago 7780050, Chile.ORCID 0000-0001-7346-9043
Instituto de Salud Pública de Chile · CLPontificia Universidad Católica de Chile · CLPontificia Universidad Católica de Valparaíso · CLSan Sebastián University · CLUniversidad del Desarrollo · CLUniversity of Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine-induced protection against pathogens, especially subunit-based vaccines, are related to antigen properties but mainly in their ability to stimulate the immune system by the use of an adjuvant. Modern vaccines are formulated with a high level of antigen purity, where an efficient adjuvant is necessary. In this context, the use of protein Toll-Like Receptor (TLR) agonists as vaccine adjuvants has been highlighted because of their optimal immunogenicity and minimal toxicity. The Surface Immunogenic Protein (SIP) from Group B

Indexed as

adjuvant proteingroup B Streptococcussurface immunogenic proteinTRL2 and TLR4 agonist

Identifiers

PMID31963234
PMCPMC7157747
OpenAlexW2999859771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.