Evidence map›Paper›PMID 31962373›Full record

ArticleMagnetic resonance in medicine2020

Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging.

Nian Wang, Anthony J Mirando, Gary Cofer, Yi Qi, Matthew J Hilton, G Allan Johnson

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Critical Systematic Review of 3D Bioprinting in Biomedicine.International journal of molecular sciences · 2025
    Pooled it
  2. Article
  3. Detecting Collagen Fiber Architecture after Destabilization of the Medial Meniscus Surgery Using High-Resolution Diffusion Tensor Imaging.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  4. Review
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  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
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  14. Applications of Diffusion-Weighted MRI to the Musculoskeletal System.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  15. Review
  16. Article
  17. Article
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  19. Article
  20. Effect ofBioMed research international · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nian WangCenter for In Vivo Microscopy, Duke University School of Medicine, Durham, North Carolina.ORCID 0000-0001-6547-8580
Anthony J MirandoDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina.
Gary CoferCenter for In Vivo Microscopy, Duke University School of Medicine, Durham, North Carolina.
Yi QiCenter for In Vivo Microscopy, Duke University School of Medicine, Durham, North Carolina.
Matthew J HiltonDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina.
G Allan JohnsonCenter for In Vivo Microscopy, Duke University School of Medicine, Durham, North Carolina.
Duke University · US

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Notch Signaling in Joint Cartilage Maintenance and ArthritisR01AR063071 · NIAMS · UNIVERSITY OF ROCHESTER · PI HILTON, MATTHEW J. · 2012 to 2021
$3.9M
Waxholm Space for Rodent NeuroinformaticsR01NS096720 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2016 to 2019
$2.4M
Notch Signaling in Endochondral Bone DevelopmentR01AR071722 · NIAMS · DUKE UNIVERSITY · PI HILTON, MATTHEW J. · 2018 to 2022
$1.8M
Agilent Direct Drive 9.4T MRS/MRI ConsoleS10OD010683 · OD · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2012
$597k
NIAMS NIH HHS R01 AR063071NIAMS NIH HHS R01 AR071722NIBIB NIH HHS P41 EB015897NIH HHS S10 OD010683NINDS NIH HHS R01 NS096720
6 · The paper itself

Abstract

purposeTo evaluate the complex fiber orientations and 3D collagen fiber network of knee joint connective tissues, including ligaments, muscle, articular cartilage, and meniscus using high spatial and angular resolution diffusion imaging.

methodsTwo rat knee joints were scanned using a modified 3D diffusion-weighted spin echo pulse sequence with the isotropic spatial resolution of 45 μm at 9.4T. The b values varied from 250 to 1250 s/mm

resultsTo better resolve the crossing fibers, the b value should be great than or equal to 1000 s/mm

conclusionHigh-resolution diffusion imaging with GQI method can trace the complex collagen fiber orientations and architectures of the knee joint at microscopic resolution.

Indexed as

Cartilage, ArticularDiffusion Tensor ImagingAnimalsCollagenDiffusion Magnetic Resonance ImagingImage Processing, Computer-AssistedKnee JointRatsCollagencartilageDTIGQImeniscusMRItractography

Identifiers

PMID31962373
PMCPMC7180110
OpenAlexW3002773389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.