Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface.

Wei Peng, Jenna L Jewell

Open access · bronzeAbstract readComment

In one paragraph

Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021
Review

4 · The record

Corrections and comments

Comment on
Architecture of human Rag GTPase heterodimers and their complex with mTORC1.2019
Comment on
Structural basis for the docking of mTORC1 on the lysosomal surface.2019

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Wei PengDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Jenna L JewellDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: Jenna.Jewell@UTSouthwestern.edu.

Howard Hughes Medical Institute · USSouthwestern Medical Center · US

Funding

Medical Research Council MC_U105184308

6 · The paper itself

Abstract

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

Indexed as

Monomeric GTP-Binding ProteinsAmino AcidsLysosomesMechanistic Target of Rapamycin Complex 1Signal TransductionAmino AcidsMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding Proteins

Identifiers

PMID31962086

DOI10.1016/j.cub.2019.11.087

OpenAlexW3000961866

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.