ArticleSchizophrenia bulletin2020
Neural Compensation Mechanisms of Siblings of Schizophrenia Patients as Revealed by High-Density EEG.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EEG microstates are a candidate endophenotype for schizophrenia.Nature communications · 2020Pooled it
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- Alpha peak frequency affects visual performance beyond temporal resolution.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The EEG multiverse of schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype.Translational psychiatry · 2022Article
- How do visual skills relate to action video game performance?Journal of vision · 2021Article
- Neural anomalies during vigilance in schizophrenia: Diagnostic specificity and genetic associations.NeuroImage. Clinical · 2020Article
- Perceptual Mechanisms of Visual Hallucinations and Illusions in Psychosis.Journal of psychiatry and brain science · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual backward masking (VBM) deficits are candidate endophenotypes of schizophrenia indexing genetic liability of the disorder. In VBM, a target is followed by a mask that deteriorates target perception. Schizophrenia patients and, to a lesser extent, their unaffected relatives show strong and reproducible VBM deficits. In patients, VBM deficits are associated with strongly decreased amplitudes in the evoked-related potentials (ERPs). Here, to unveil the neural mechanisms of VBM in schizophrenia, circumventing illness-specific confounds, we investigated the electroencephalogram correlates of VBM in unaffected siblings of schizophrenia patients. We tested 110 schizophrenia patients, 60 siblings, and 83 healthy controls. As in previous studies, patients showed strong behavioral deficits and decreased ERP amplitudes compared to controls. Surprisingly, the ERP amplitudes of siblings were even higher than the ones of controls, while their performances were similar. ERP amplitudes in siblings were found to correlate with performance. These results suggest that VBM is deteriorated in patients and siblings. However, siblings, unlike patients, can partially compensate for the deficits by over-activating a network of brain regions.
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