ArticlePLoS neglected tropical diseases2020
Phylogenetic relationships and diversity of bat-associated Leptospira and the histopathological evaluation of these infections in bats from Grenada, West Indies.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 27 citations in OpenAlex.
- Infectome analysis of bat kidneys from Yunnan province, China, reveals novel henipaviruses related to Hendra and Nipah viruses and prevalent bacterial and eukaryotic microbes.PLoS pathogens · 2025Article
- Grenadian cats as potential reservoir for Leptospira.PLoS neglected tropical diseases · 2024Article
- Bat Ecology and Microbiome of the Gut: A Narrative Review of Associated Potentials in Emerging and Zoonotic Diseases.Animals : an open access journal from MDPI · 2024Review
- Review
- Prevalence and Characteristics of Novel PathogenicMicroorganisms · 2023Article
- Neuro-leptospirosis - A batty diagnostic enigma.IDCases · 2023Article
- Leptospira interrogans in bats in Rio Grande do Sul State, Brazil: epidemiologic aspects and phylogeny.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Diversity of Leptospira spp. in bats and rodents from Papua New Guinea.Transboundary and emerging diseases · 2022Article
- Molecular detection ofParasitology · 2022Article
- An overview of bats microbiota and its implication in transmissible diseases.Frontiers in microbiology · 2022Review
- The Kidney-Associated Microbiome of Wild-CaughtAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bats can harbor zoonotic pathogens, but their status as reservoir hosts for Leptospira bacteria is unclear. During 2015-2017, kidneys from 47 of 173 bats captured in Grenada, West Indies, tested PCR-positive for Leptospira. Sequence analysis of the Leptospira rpoB gene from 31 of the positive samples showed 87-91% similarity to known Leptospira species. Pairwise and phylogenetic analysis of sequences indicate that bats from Grenada harbor as many as eight undescribed Leptospira genotypes that are most similar to known pathogenic Leptospira, including known zoonotic serovars. Warthin-Starry staining revealed leptospiral organisms colonizing the renal tubules in 70% of the PCR-positive bats examined. Mild inflammatory lesions in liver and kidney observed in some bats were not significantly correlated with renal Leptospira PCR-positivity. Our findings suggest that Grenada bats are asymptomatically infected with novel and diverse Leptospira genotypes phylogenetically related to known pathogenic strains, supporting the hypothesis that bats may be reservoirs for zoonotic Leptospira.
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