Evidence map›Paper›PMID 31961762›Full record

Trial reportPhysiological genomics2020

Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer's disease.

Lucas A C Souza, Fatima Trebak, Veena Kumar, Ryousuke Satou, Patrick G Kehoe, Wei Yang, Whitney Wharton, Yumei Feng Earley

Open access · bronzeAbstract readClinical TrialObservational Study
In one paragraph

Trial report in Physiological genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Elevated NaInternational journal of molecular sciences · 2026
    Article
  2. Elevated NabioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Metals in Alzheimer's Disease.Biomedicines · 2023
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lucas A C SouzaDepartments of Pharmacology and Physiology & Cell Biology, University of Nevada, Reno, School of Medicine, Reno, Nevada.
Fatima TrebakDepartments of Pharmacology and Physiology & Cell Biology, University of Nevada, Reno, School of Medicine, Reno, Nevada.
Veena KumarDepartment of Neurology, Emory University School of Nursing, Atlanta, Georgia.
Ryousuke SatouDepartment of Physiology, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0001-6505-9722
Patrick G KehoeInstitute of Clinical Neurosciences, University of Bristol, Bristol, United Kingdom.
Wei YangUniversity of Nevada, Reno, School of Community Health Sciences, Reno, Nevada.
Whitney WhartonDepartment of Neurology, Emory University School of Nursing, Atlanta, Georgia.
Yumei Feng EarleyDepartments of Pharmacology and Physiology & Cell Biology, University of Nevada, Reno, School of Medicine, Reno, Nevada.ORCID 0000-0002-4138-0105
University of Nevada, Reno · USEmory University · USTulane University · USUniversity of Bristol · GB

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
TRP Channel-Dependent Regulation of Arterial Tone (Renewal)R01HL091905 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2009 to 2020
$5.1M
The Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI FENG EARLEY, YUMEI · 2015 to 2023
$4.2M
Preclinical Alzheimer's Disease Biomarkers: Effects of Midlife Vascular FactorsK01AG042498 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI WHARTON, WHITNEY LEE · 2013 to 2017
$617k
NHLBI NIH HHS R01 HL091905NHLBI NIH HHS R01 HL122770NIA NIH HHS K01 AG042498NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

High salt (sodium) intake leads to the development of hypertension despite the fact that plasma sodium concentration ([Na

Indexed as

Alzheimer DiseaseMedical History TakingAgedBlood PressureFemaleGeorgiaHumansHypertensionIncidenceMaleMiddle AgedRetrospective StudiesSex FactorsSodiumSodium Chloride, DietarySodiumSodium Chloride, DietaryAlzheimer’s diseasecerebrospinal fluidhypertensionosmolalitysodium

Identifiers

PMID31961762
PMCPMC7099411
OpenAlexW3000995956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.