Evidence map›Paper›PMID 31961720›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy.

So Yeon Kim, Kang Ho Kim, Jan M Schilling, Joseph Leem, Mehul Dhanani, Brian P Head, David M Roth, Alice E Zemljic-Harpf, Hemal H Patel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Caveolin-3 and Caveolae regulate ventricular repolarization.Journal of molecular and cellular cardiology · 2023
    Article
  4. Article
  5. Short histological kaleidoscope - recent findings in histology. Part III.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

So Yeon KimDepartment of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kang Ho KimDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
Jan M SchillingVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.
Joseph LeemVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.
Mehul DhananiVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.
Brian P HeadVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.
David M RothVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.
Alice E Zemljic-HarpfVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.
Hemal H PatelVeterans Administration San Diego Healthcare System and the Department of Anesthesiology, University of California, San Diego, School of Medicine, San Diego, California.ORCID 0000-0001-6722-9625
University of California San Diego · USBaylor College of Medicine · USYonsei University · KR

Funding

Caveolae, mitochondria, and cardiac protection.R01HL091071 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H · 2008 to 2019
$3.8M
Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.I01BX000783 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI ROTH, DAVID M · 2011 to 2019
–
Novel Therapeutics for Diabetic CardiomyopathyI01BX001963 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PATEL, HEMAL H · 2013 to 2025
–
Caveolin-Mediated Neuroplasticity in Alzheimer's Disease and in Human Neurons Harboring EOFAD MutationsI01BX003671 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HEAD, BRIAN P · 2017 to 2024
–
BLRD VA I01 BX000783BLRD VA I01 BX001963BLRD VA I01 BX003671NHLBI NIH HHS R01 HL091071
6 · The paper itself

Abstract

Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critical role in cardiac protection and is an emerging therapeutic target for heart disease. We investigated the protective role of cardiac-specific overexpression (OE) of Cav-3 in cirrhotic cardiomyopathy. Biliary fibrosis was induced in male Cav-3 OE mice and transgene negative (TG

Indexed as

Action PotentialsAnimalsCardiomyopathiesCaveolin 3Disease Models, AnimalHeart RateIsolated Heart PreparationLiver Cirrhosis, BiliaryMaleMice, Inbred C57BLMice, TransgenicMyocardial ContractionMyocardiumPyridinesSignal TransductionTime Factors3,5-diethoxycarbonyl-1,4-dihydrocollidineCav3 protein, mouseCaveolin 3Pyridinesadrenergiccaveolincirrhotic cardiomyopathy

Identifiers

PMID31961720
PMCPMC7099497
OpenAlexW3002588361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.