Evidence map›Paper›PMID 31961718›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome.

Isabelle R Miousse, Laura E Ewing, Charles M Skinner, Rupak Pathak, Sarita Garg, Kristy R Kutanzi, Stepan Melnyk, Martin Hauer-Jensen, Igor Koturbash

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Targeting gut microbiota and metabolites in cancer radiotherapy.Clinical and translational medicine · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Interactions between Radiation and One-Carbon Metabolism.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Isabelle R MiousseDepartment of Environmental and Occupation Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Laura E EwingDepartment of Environmental and Occupation Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Charles M SkinnerDepartment of Environmental and Occupation Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Rupak PathakDivision of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Sarita GargDivision of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Kristy R KutanziDepartment of Environmental and Occupation Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Stepan MelnykArkansas Children's Research Institute, Little Rock, Arknsas.
Martin Hauer-JensenDivision of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Igor KoturbashDepartment of Environmental and Occupation Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas.ORCID 0000-0002-4090-7008
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · US

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1M
Institutional Career DevelopmentKL2TR003108 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI ARTHUR, JOHN M., BORSHEIM, ELISABET · 2019 to 2023
$2.3M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
NCATS NIH HHS KL2 TR003108NCATS NIH HHS UL1 TR003107NIGMS NIH HHS P20 GM109005NIGMS NIH HHS T32 GM106999
6 · The paper itself

Abstract

Methionine is an essential amino acid needed for a variety of processes in living organisms. Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA methylation and decreased synthesis of glutathione. In this study, we aimed to investigate the effects of methionine dietary supplementation in CBA/CaJ mice after exposure to doses ranging from 3 to 8.5 Gy of

Indexed as

Acute Radiation SyndromeAnimalsDietary SupplementsDNA MethylationDysbiosisEnergy MetabolismGastrointestinal MicrobiomeIntestine, SmallMaleMethionineMice, Inbred C57BLMice, Inbred CBARadiation DosageRadiation Injuries, ExperimentalRisk FactorsWhole-Body IrradiationMethioninedietary supplementationgastrointestinal toxicityionizing radiationmethioninemicrobiome

Identifiers

PMID31961718
PMCPMC7099489
OpenAlexW3001444316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.