Evidence map›Paper›PMID 31961670›Full record

ArticleACS synthetic biology2020

Light-Inducible Recombinases for Bacterial Optogenetics.

Michael B Sheets, Wilson W Wong, Mary J Dunlop

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
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  3. Tunable low-rate genomic recombination with Cre-Applied and environmental microbiology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael B SheetsDepartment of Biomedical Engineering , Boston University , Boston , Massachusetts 02215 , United States.
Wilson W WongDepartment of Biomedical Engineering , Boston University , Boston , Massachusetts 02215 , United States.ORCID 0000-0001-8394-889X
Mary J DunlopDepartment of Biomedical Engineering , Boston University , Boston , Massachusetts 02215 , United States.ORCID 0000-0002-9261-8216
Boston University · US

Funding

Feedback and Noise in a Multiple Antibiotic Resistance CircuitR01AI102922 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Mary J. Dunlop · 2014 to 2026
$4.7M
Translational Research in BiomaterialsT32EB006359 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Michelle H Teplensky · 2009 to 2026
$4.2M
Synthetically Reengineered T cells as the Next Generation of Smart Cancer TherapyDP2CA186574 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WONG, WILSON · 2013 to 2013
$2.5M
Advanced recombinase-based gene expression technology in mammalian cellsR01GM129011 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WONG, WILSON · 2019 to 2022
$1.5M
Efflux pumps and the emergence of antibiotic resistance in single cellsR21AI137843 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DUNLOP, MARY · 2018 to 2019
$453k
Biotechnology and Biological Sciences Research CouncilNCI NIH HHS DP2 CA186574NIAID NIH HHS R01 AI102922NIAID NIH HHS R21 AI137843NIBIB NIH HHS T32 EB006359NIGMS NIH HHS R01 GM129011
6 · The paper itself

Abstract

Optogenetic tools can provide direct and programmable control of gene expression. Light-inducible recombinases, in particular, offer a powerful method for achieving precise spatiotemporal control of DNA modification. However, to-date this technology has been largely limited to eukaryotic systems. Here, we develop optogenetic recombinases for

Indexed as

LightDimerizationEscherichia coliGenes, ReporterIntegrasesLuminescent ProteinsMicroscopy, FluorescenceOptogeneticsRed Fluorescent ProteinCre recombinaseIntegrasesLuminescent ProteinsRed Fluorescent ProteinCreinducible recombinaseoptogeneticsphotoactivationrecombinase

Identifiers

PMID31961670
PMCPMC7393974
OpenAlexW3002209456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.