Evidence map›Paper›PMID 31961495›Full record

Observational studyArthritis care & research2021

Knee Osteoarthritis, Potential Mediators, and Risk of All-Cause Mortality: Data From the Osteoarthritis Initiative.

Yilun Wang, Uyen-Sa D T Nguyen, Nancy E Lane, Na Lu, Jie Wei, Guanghua Lei, Chao Zeng, Yuqing Zhang

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Yilun WangXiangya Hospital, Central South University, Changsha, China.
Uyen-Sa D T NguyenUniversity of North Texas Health Science Center, Fort Worth, and Boston University School of Medicine, Boston, Massachusetts.
Nancy E LaneUniversity of California, Davis.
Na LuArthritis Research Canada, Richmond, British Columbia, Canada.
Jie WeiThe Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and Xiangya Hospital, Central South University, Changsha, China.
Guanghua LeiXiangya Hospital, Central South University, Hunan Key Laboratory of Joint Degeneration and Injury, and National Clinical Research Center of Geriatric Disorders (Xiangya), Changsha, China.ORCID 0000-0003-2987-138X
Chao ZengThe Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and Xiangya Hospital, Central South University, Changsha, China.
Yuqing ZhangThe Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0001-7638-0888
Harvard University · USCentral South University · CNBoston University · USResearch Canada · CAUniversity of California, Davis · US

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
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CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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NEW PHARMACOLOGY ASPECTS RELATED TO CARBONIC ANHYDRASER01HL022258 · NHLBI · UNIVERSITY OF FLORIDA · PI MAREN, THOMAS H · 1985 to 1986
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NHLBI NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262the National Institutes of Health, a branch of the Department of Health and Human Services and conducted by the OAI Study Investigators N01-AR-2-2258the National Institutes of Health, a branch of the Department of Health and Human Services and conducted by the OAI Study Investigators N01-AR-2-2259the National Institutes of Health, a branch of the Department of Health and Human Services and conducted by the OAI Study Investigators N01-AR-2-2260the National Institutes of Health, a branch of the Department of Health and Human Services and conducted by the OAI Study Investigators N01-AR-2-2261the National Institutes of Health, a branch of the Department of Health and Human Services and conducted by the OAI Study Investigators N01-AR-2-2262
6 · The paper itself

Abstract

objectiveTo assess the relation of symptomatic knee osteoarthritis (OA), knee pain, and radiographic knee OA to All-cause mortality and to identify mediators in the causal pathway.

methodsParticipants from the Osteoarthritis Initiative were divided into 4 groups: 1) symptomatic knee OA (i.e., both radiographic knee OA [Kellgren/Lawrence grade ≥2] and knee pain); 2) knee pain only; 3) radiographic knee OA only; and 4) neither radiographic knee OA nor knee pain. We examined the relation of knee OA status to All-cause mortality using a multivariable Cox proportional hazards model and assessed the extent to which the association was mediated by disability, physical component summary (PCS) and mental component summary (MCS) scores for quality of life (QoL), and use of oral pain-relief medications (i.e., nonsteroidal antiinflammatory drugs and opioids).

resultsAmong 4,796 participants, 282 died over the 96-month follow-up period. Compared with those with neither radiographic knee OA nor knee pain, multivariable-adjusted hazard ratios (HRs) of mortality were 2.2 (95% confidence interval [95% CI] 1.6-3.1) for symptomatic knee OA, 0.9 (95% CI 0.6-1.4) for knee pain only, and 2.0 (95% CI 1.4-2.9) for radiographic knee OA only, respectively. Indirect effects (HRs) of symptomatic knee OA on mortality via disability and PCS of QoL were 1.1 (95% CI 1.0-1.4) and 1.2 (95% CI 1.0-1.4), respectively. No apparent mediation effect was observed through either MCS of QoL or oral pain-relief medications use.

conclusionParticipants with either symptomatic or radiographic knee OA were at an increased risk of All-cause mortality. Increased risk of mortality from symptomatic knee OA was partially mediated through its effect on disability and PCS of QoL.

Indexed as

AgedAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalArthralgiaDisability EvaluationFemaleFunctional StatusHumansKnee JointMaleMiddle AgedOsteoarthritis, KneePain MeasurementPrognosisQuality of LifeRisk AssessmentAnalgesics, OpioidAnti-Inflammatory Agents, Non-Steroidal

Identifiers

PMID31961495
PMCPMC8606227
OpenAlexW3001148064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.