Evidence map›Paper›PMID 31961138›Full record

ArticleBioconjugate chemistry2020

Antibody Targeted PET Imaging of

Patty Wong, Lin Li, Junie Chea, Weidong Hu, Erasmus Poku, Todd Ebner, Nicole Bowles, Jeffrey Y C Wong, Paul J Yazaki, Stephen Sligar and 1 more

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Kupffer Cell Capture-Evading Modifiable Sub-20 nm Lipid Nanodisc-BasedJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. ACS medicinal chemistry letters · 2024
    Article
  5. Review
  6. Review
  7. Immuno-PET of colorectal cancer with a CEA-targeted [68 Ga]Ga-nanobody: from bench to bedside.European journal of nuclear medicine and molecular imaging · 2023
    Article
  8. Article
  9. Article
  10. Single-component nanodiscsChemical science · 2022
    Article
  11. Review
  12. Review
  13. Nanodiscs: A toolkit for membrane protein science.Protein science : a publication of the Protein Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Patty WongDepartment of Radiation Oncology, City of Hope Medical Center, Duarte, California 91010, United States.
Lin LiDepartment of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.
Junie CheaRadiopharmacy, City of Hope Medical Center, Duarte, California 91010, United States.
Weidong HuDepartment of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.
Erasmus PokuRadiopharmacy, City of Hope Medical Center, Duarte, California 91010, United States.
Todd EbnerDepartment of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.
Nicole BowlesRadiopharmacy, City of Hope Medical Center, Duarte, California 91010, United States.
Jeffrey Y C WongDepartment of Radiation Oncology, City of Hope Medical Center, Duarte, California 91010, United States.
Paul J YazakiDepartment of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.
Stephen SligarDepartment of Molecular and Cellular Biology, University of Illinois, Urbana, Illinois 61801, United States.ORCID 0000-0002-5548-2866
John E ShivelyDepartment of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.ORCID 0000-0002-7763-770X
City of Hope · USCity Of Hope National Medical Center · USUniversity of Illinois Urbana-Champaign · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

Lipid nanodiscs (LNDs), comprising a phospholipid bilayer encircled by two molecules of a recombinant membrane scaffold protein, can be targeted to tumors with covalently attached antibodies (Abs) or their fragments. Antibody attachment to click chemistry based PEGylated lipids on LNDs including DOTA allowed PET imaging with the positron emitter

Indexed as

AnimalsAzidesCarcinoembryonic AntigenCell Line, TumorCopper RadioisotopesFemaleHeterocyclic Compounds, 1-RingImmunoconjugatesMammary Neoplasms, ExperimentalMiceNanostructuresPhospholipidsPolyethylene GlycolsPositron-Emission Tomography1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidAzidesCarcinoembryonic AntigenCopper-64Copper RadioisotopesHeterocyclic Compounds, 1-RingImmunoconjugatesPhospholipidsPolyethylene Glycols

Identifiers

PMID31961138
PMCPMC8818266
OpenAlexW3001936394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.