ArticleThe Journal of infectious diseases2020
Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Tac1 deficiency reduces the severity of enteric bacterial infection.PLoS pathogens · 2026Article
- Neuroimmune Interactions in Inflammatory Skin and Intestinal Diseases.Journal of inflammation research · 2026Review
- The sympathetic nervous system enhances host immune responses to enteric bacterial pathogens in mice.Brain, behavior, and immunity · 2025Article
- Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation.Science advances · 2025Article
- Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- 2023 Workshop: Neuroimmune Crosstalk in the Gut - Impact on Local, Autonomic and Gut-Brain Function.Gastroenterology · 2024Article
- Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection.bioRxiv : the preprint server for biology · 2024Article
- From pain to meningitis: bacteria hijack nociceptors to promote meningitis.Frontiers in immunology · 2024Review
- TRPV1 controls innate immunity during Citrobacter rodentium enteric infection.PLoS pathogens · 2023Article
- Ion channel regulation of gut immunity.The Journal of general physiology · 2023Article
- The diversity of neuroimmune circuits controlling lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2023Review
- N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.Journal of neuroinflammation · 2022Article
- Review
- Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation.The Journal of physiology · 2021Article
- Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay.Frontiers in pharmacology · 2021Review
- Neural Immune Communication in the Control of Host-Bacterial Pathogen Interactions in the Gastrointestinal Tract.Infection and immunity · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeurons are an integral component of the immune system that functions to coordinate responses to bacterial pathogens. Sensory nociceptive neurons that can detect bacterial pathogens are found throughout the body with dense innervation of the intestinal tract.
methodsIn this study, we assessed the role of these nerves in the coordination of host defenses to Citrobacter rodentium. Selective ablation of nociceptive neurons significantly increased bacterial burden 10 days postinfection and delayed pathogen clearance.
resultsBecause the sensory neuropeptide CGRP (calcitonin gene-related peptide) regulates host responses during infection of the skin, lung, and small intestine, we assessed the role of CGRP receptor signaling during C rodentium infection. Although CGRP receptor blockade reduced certain proinflammatory gene expression, bacterial burden and Il-22 expression was unaffected.
conclusionsOur data highlight that sensory nociceptive neurons exert a significant host protective role during C rodentium infection, independent of CGRP receptor signaling.
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Registered trials
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