Evidence map›Paper›PMID 31960836›Full record

ArticleThe Analyst2020

Measurement of serum phosphate levels using a mobile sensor.

Aniruddha Ray, Sarah Esparza, Dimei Wu, Mark R Hanudel, Hyou-Arm Joung, Barbara Gales, Derek Tseng, Isidro B Salusky, Aydogan Ozcan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Analyst, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aniruddha RayDepartment of Electrical and Computer Engineering, University of California, Los Angeles, CA 90095, USA. ozcan@ucla.edu and Department of Bioengineering, University of California, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA and Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. isalusky@mednet.ucla.edu and Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606, USA.ORCID http://orcid.org/0000-0003-2561-2217
Sarah EsparzaDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Dimei WuDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.ORCID http://orcid.org/0000-0002-2362-9755
Mark R HanudelDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. isalusky@mednet.ucla.edu.
Hyou-Arm JoungDepartment of Electrical and Computer Engineering, University of California, Los Angeles, CA 90095, USA. ozcan@ucla.edu and Department of Bioengineering, University of California, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA.ORCID http://orcid.org/0000-0001-5106-4459
Barbara GalesDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. isalusky@mednet.ucla.edu.
Derek TsengDepartment of Electrical and Computer Engineering, University of California, Los Angeles, CA 90095, USA. ozcan@ucla.edu and Department of Bioengineering, University of California, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA.
Isidro B SaluskyDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. isalusky@mednet.ucla.edu.
Aydogan OzcanDepartment of Electrical and Computer Engineering, University of California, Los Angeles, CA 90095, USA. ozcan@ucla.edu and Department of Bioengineering, University of California, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA and Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID http://orcid.org/0000-0002-0717-683X
University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Translational Research Training in Pediatric NephrologyT32DK104687 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALUSKY, ISIDRO B. · 2015 to 2019
$879k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIDDK NIH HHS T32 DK104687
6 · The paper itself

Abstract

The measurement of serum phosphate concentration is crucial for patients with advanced chronic kidney disease (CKD) and those on maintenance dialysis, as abnormal phosphate levels may be associated with severe health risks. It is important to monitor serum phosphate levels on a regular basis in these patients; however, such measurements are generally limited to every 0.5-3 months, depending on the severity of CKD. This is due to the fact that serum phosphate measurements can only be performed at regular clinic visits, in addition to cost considerations. Here we present a portable and cost-effective point-of-care device capable of measuring serum phosphate levels using a single drop of blood (<60 μl). This is achieved by integrating a paper-based microfluidic platform with a custom-designed smartphone reader. This mobile sensor was tested on patients undergoing dialysis, where whole blood samples were acquired before starting the hemodialysis and during the three-hour treatment. This sampling during the hemodialysis, under patient consent, allowed us to test blood samples with a wide range of phosphate concentrations, and our results showed a strong correlation with the ground truth laboratory tests performed on the same patient samples (Pearson coefficient r = 0.95 and p < 0.001). Our 3D-printed smartphone attachment weighs about 400 g and costs less than 80 USD, whereas the material cost for the disposable test is <3.5 USD (under low volume manufacturing). This low-cost and easy-to-operate system can be used to measure serum phosphate levels at the point-of-care in about 45 min and can potentially be used on a daily basis by patients at home.

Indexed as

CalorimetryDiagnostic Tests, RoutineHumansKidney Failure, ChronicPhosphatesPoint-of-Care SystemsSmartphonePhosphates

Identifiers

PMID31960836
PMCPMC7058527
OpenAlexW3000596649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.