Evidence map›Paper›PMID 31960568›Full record

ArticleJournal of separation science2020

Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis.

Samuel W Foster, Xiaofeng Xie, Michelle Pham, Paul A Peaden, Leena M Patil, Luke T Tolley, Paul B Farnsworth, H Dennis Tolley, Milton L Lee, James P Grinias

Open access · greenAbstract read
In one paragraph

Article in Journal of separation science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 57 citations in OpenAlex.

  1. A Unified Analytical Method Greenness Score (ACS sustainable chemistry & engineering · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Samuel W FosterDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ.
Xiaofeng XieAxcend Corporation, Provo, UT.
Michelle PhamDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ.
Paul A PeadenAxcend Corporation, Provo, UT.
Leena M PatilDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT.
Luke T TolleyAxcend Corporation, Provo, UT.
Paul B FarnsworthDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT.
H Dennis TolleyDepartment of Statistics, Brigham Young University, Provo, UT.
Milton L LeeAxcend Corporation, Provo, UT.
James P GriniasDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ.ORCID https://orcid.org/0000-0001-9872-9630
Brigham Young University · USRowan University · USTranscend Engineering (United States) · US

Funding

Portable Liquid Chromatograph for Point-of-Care Monitoring of Illicit SubstancesR41DA045382 · NIDA · AXCEND, LLC · PI GRINIAS, JAMES P, TOLLEY, LUKE · 2018 to 2018
$135k
NIDA NIH HHS R41 DA045382
6 · The paper itself

Abstract

A newly developed portable capillary liquid chromatograph was investigated for the separation of various pharmaceutical and illicit drug compounds. The system consists of two high-pressure syringe pumps capable of delivering capillary-scale flow rates at pressures up to 10 000 psi. Capillary liquid chromatography columns packed with sub-2 μm particles are housed in cartridges that can be inserted into the system and easily connected through high-pressure fluidic contact points by simply applying a specific, predetermined torque rather than using standard fittings and less precise sealing protocols. Several over-the-counter analgesic drug separations are demonstrated, along with a simple online measurement of tablet dissolution. Twenty illicit drug compounds were also separated across six targeted drug panels. The results described in this study demonstrate the capability of this compact liquid chromatography instrument to address several important drug-related applications while simplifying system operation, and greatly reducing solvent usage and waste generation essential for onsite analysis.

Indexed as

Chromatography, LiquidForensic SciencesIllicit DrugsIllicit Drugscapillary liquid chromatographydissolution monitoringillicit drugspharmaceuticalsportable

Identifiers

PMID31960568
PMCPMC7263832
OpenAlexW3001700699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.