ArticleClinical & experimental metastasis2020
Impact of decompressive laminectomy on the functional outcome of patients with metastatic spinal cord compression and neurological impairment.
Article in Clinical & experimental metastasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Systematic Review and Meta-Analysis on Optimal Timing of Surgery for Acute Symptomatic Metastatic Spinal Cord Compression.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Evaluating ambulatory function as an outcome following treatment for spinal metastases: a systematic review.The spine journal : official journal of the North American Spine Society · 2021Pooled it
- Clinical Determinants of Functional Independence at Discharge in Patients With Spinal Cord Dysfunction Due to Metastatic Spinal Tumors.Archives of rehabilitation research and clinical translation · 2026Article
- [Indication and outcome of salvage surgery for urogenital malignancies].Urologie (Heidelberg, Germany) · 2026Article
- Article
- The Missing Link: Integrating Interventional Pain Management in the Era of Multimodal Oncology.Pain and therapy · 2025Review
- Article
- Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway.Frontiers in immunology · 2025Article
- Article
- Expected motor function change following decompressive surgery for spinal metastatic disease.North American Spine Society journal · 2023Article
- Risk Factors for Poor Outcome after Palliative Surgery for Metastatic Spinal Tumors.Journal of clinical medicine · 2023Article
- Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review.The Lancet. Oncology · 2022Article
- Spinal oncologic paraparesis: Analysis of neurological and surgical outcomes in patients with intramedullary, extramedullary, and extradural tumors.Frontiers in oncology · 2022Article
- A systematic review of MIS and open decompression surgery for spinal metastases in the last two decades.Journal of clinical orthopaedics and trauma · 2021Review
- Clinical study on improving postoperative symptoms of cervical spondylotic myelopathy by Qishe pill.Medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a single center retrospective cohort study of neurologically impaired MSCC-patients treated with decompressive laminectomy between 2004 and 2014 was performed. 101 patients (27 female/74 male; age 66.1 ± 11.5 years) were identified. Prostate was the most common primary tumor site (40%) and progressive disease was present in 74%. At admission, 80% of patients were non-ambulatory (FG A-C). Imaging revealed prevalently thoracic MSCC (78%). Emergency surgery (< 24 h) was performed in 71% and rates of complications and revision surgery were 6% and 4%, respectively. At discharge, FG had improved in 61% of cases, and 51% of patients had regained ambulation. Univariate predictors for not regaining the ability to walk were bowl dysfunction (p = 0.0015), KPI < 50% (p = 0.048) and FG < C (p = 0.001) prior to surgery. In conclusion, decompressive laminectomy showed beneficial effects on the functional outcome at discharge. A good neurological status prior to surgery was key predictor for a good functional outcome.
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