ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2020
Evaluation of serological diagnostic tests of human brucellosis for prevention and control in Mexico.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Efficacy ofTransboundary and emerging diseases · 2024Pooled it
- Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis.Frontiers in veterinary science · 2022Pooled it
- Seasonal dynamic modeling for real-time prediction of human brucellosis epidemiological trends in Gansu, Guangdong and Sichuan Provinces, China.PLoS neglected tropical diseases · 2026Article
- Brucellosis Seroprevalence, Analysis of Risk Factors, and Comparison of Test Methods Used in Diagnosis in a Tertiary Hospital in Kahramanmaraş.Tropical medicine and infectious disease · 2026Article
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- Spatiotemporal dynamics and influencing factors of human brucellosis in Mainland China from 2005-2021.BMC infectious diseases · 2024Article
- Article
- Comparison of the Characteristics of Brucella Patients Diagnosed With Blood Culture Positivity and/or Serology.Cureus · 2023Article
- Evaluating the efficacy of serological testing of clinical specimens collected from patients with suspected brucellosis.PLoS neglected tropical diseases · 2023Article
- Gold Nanobiosensor Based on the Localized Surface Plasmon Resonance is Able to Diagnose Human Brucellosis, Introducing a Rapid and Affordable Method.Nanoscale research letters · 2021Article
- Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis is a zoonosis mainly present in developing countries. The WHO reports 500,000 new cases every year. From 2012 to 2016, 13,677 cases were reported in Mexico, with 2.00 to 2.64 rate per 100,000 inhabitants. To analyze the diagnostic algorithm of brucellosis in Mexico, we compared the commercial laboratory tests ELISA, Brucellacapt®, and lateral flow test (LFT) in a study of 473 individuals from two endemic Mexican populations. All patients were treated in first-level medical units for presenting brucellosis compatible symptoms and without a history of the disease. Clinical-epidemiological information was gathered and initial serum samples were obtained to react with anti-Brucella antibodies; subsequent samples were collected at follow-up treatment visits. Using the Rose Bengal screening, we found 165 negative samples and 308 positive reactive samples, of which 222 cases were confirmed and 234 were positive on at least one marker (IgG or IgM) or LFT. When Brucellacapt® was used, similar results to those observed with the conventional algorithm were found as judged by the Cohen's kappa coefficient (κ) (0.813, 95% CI 0.7788-0.8472). Similar κ indices between conventional algorithm and ELISA pair were found, 0.7038 (95% CI 0.6555-0.7521), representing high similarity between both groups of diagnosis. We conclude that conventional serodiagnoses, Brucellacapt® and LFT, presented inconclusive results and poor correlation between them. By contrast, ELISA test pair (IgG + IgM) presented high correlation with the conventional algorithm and greater capacity for correct positive and negative classification.
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