Evidence map›Paper›PMID 31960114›Full record

ArticleCellular and molecular life sciences : CMLS2020

Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation.

Stefan Schäbler, Kelechi M Amatobi, Melanie Horn, Dirk Rieger, Charlotte Helfrich-Förster, Martin J Mueller, Christian Wegener, Agnes Fekete

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026
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  15. Model and Non-model Insects in Chronobiology.Frontiers in behavioral neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stefan SchäblerPharmaceutical Biology, Julius-Von-Sachs-Institute, Biocenter, University of Würzburg, Julius-von-Sachs Platz 2, 97084, Würzburg, Germany.
Kelechi M AmatobiPharmaceutical Biology, Julius-Von-Sachs-Institute, Biocenter, University of Würzburg, Julius-von-Sachs Platz 2, 97084, Würzburg, Germany.
Melanie HornNeurobiology and Genetics, Würzburg Insect Research, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Dirk RiegerNeurobiology and Genetics, Würzburg Insect Research, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.ORCID http://orcid.org/0000-0001-5597-5858
Charlotte Helfrich-FörsterNeurobiology and Genetics, Würzburg Insect Research, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.ORCID http://orcid.org/0000-0002-0859-9092
Martin J MuellerPharmaceutical Biology, Julius-Von-Sachs-Institute, Biocenter, University of Würzburg, Julius-von-Sachs Platz 2, 97084, Würzburg, Germany.ORCID http://orcid.org/0000-0001-8122-5460
Christian WegenerNeurobiology and Genetics, Würzburg Insect Research, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, 97074, Würzburg, Germany. christian.wegener@biozentrum.uni-wuerzburg.de.ORCID http://orcid.org/0000-0003-4481-3567
Agnes FeketePharmaceutical Biology, Julius-Von-Sachs-Institute, Biocenter, University of Würzburg, Julius-von-Sachs Platz 2, 97084, Würzburg, Germany. agnes.fekete@uni-wuerzburg.de.ORCID http://orcid.org/0000-0003-3058-7570
University of Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft (DFG) SFB1047, Project A1Deutsche Forschungsgemeinschaft (DFG) SFB1047, Project A4Deutsche Forschungsgemeinschaft (DFG) SFB1047, Project B2Deutsche Forschungsgemeinschaft (DFG) SFB1047, Project B5Graduate School of Life Sciences, University of Wuerzburg (DE) PhD Scholarship
6 · The paper itself

Abstract

The fruit fly Drosophila is a prime model in circadian research, but still little is known about its circadian regulation of metabolism. Daily rhythmicity in levels of several metabolites has been found, but knowledge about hydrophobic metabolites is limited. We here compared metabolite levels including lipids between period

Indexed as

AnimalsBiomarkersCarnitineCircadian ClocksCircadian RhythmDrosophila melanogasterDrosophila ProteinsFeeding BehaviorLipid MetabolismLipidsLoss of Function MutationMaleMetabolomeMotor ActivityPeriod Circadian ProteinsStarvationacylcarnitineBiomarkersCarnitineDrosophila ProteinsLipidsPeriod Circadian ProteinsPER protein, DrosophilaTryptophanAcylcarnitineCircadian rhythmsFeedingMetabolomicsMitochondrial activityTryptophan

Identifiers

PMID31960114
PMCPMC7658074
OpenAlexW3002530420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.