ArticleRheumatology (Oxford, England)2020
Opioid prescriptions in patients with osteoarthritis: a population-based cohort study.
Article in Rheumatology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Core Recommendations for Osteoarthritis Care: A Systematic Review of Clinical Practice Guidelines.Arthritis care & research · 2023Pooled it
- Psychiatric, Cardiovascular and Skeletal Risks of Codeine versus Oxycodone in Hip Osteoarthritis: A Population-Based Cohort Study.Drug design, development and therapy · 2026Article
- Carpometacarpal Osteoarthritis Is Associated With an Increased Risk of Carpal Tunnel Syndrome.Journal of hand surgery global online · 2026Article
- Association of analgesics prescription with incident comorbidities in people with osteoarthritis-a UK primary care database cohort study.Rheumatology advances in practice · 2026Article
- Patterns of analgesic utilisation among people with knee osteoarthritis: a cohort study using UK primary care data.Journal of pharmaceutical policy and practice · 2025Article
- Beyond Boundaries of a Trial: Post-Market Clinical Follow-Up of SOYA Patients.Journal of clinical medicine · 2024Article
- Trends for opioid prescribing and the impact of the COVID-19 pandemic in patients with rheumatic and musculoskeletal diseases between 2006 and 2021.Rheumatology (Oxford, England) · 2024Article
- Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Alleviates Inflammatory Joint Pain in Osteoarthritis and Gouty Arthritis Preclinical Models.Journal of pain research · 2024Article
- Opioids for Osteoarthritis: Cross-Sectional Survey of Patient Perspectives and Satisfaction.Journal of clinical medicine · 2023Article
- Antidepressant and anticonvulsant prescription rates in patients with osteoarthritis: a population-based cohort study.Rheumatology (Oxford, England) · 2021Article
- The evolution of nerve growth factor inhibition in clinical medicine.Nature reviews. Rheumatology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated with the prescription of opioids were assessed.
methodsA population-based cohort study was conducted using the Integrated Primary Care Information database. Incidence and prevalence of opioid prescriptions were calculated for the period 2008-2017. Logistic regression was used to assess which patient characteristics were associated with opioid prescriptions.
resultsIn total, 157 904 OA patients were included. The overall prescription rate remained fairly stable, at around 100 incident and 170 prevalent prescriptions per 1000 person years. However, the incident prescription rate for oxycodone increased from 7.1 to 40.7 per 1000 person years and for fentanyl from 4.2 to 7.4 per 1000 person years. The incident prescription rate for paracetamol/codeine decreased from 63.0 to 13.3 per 1000 person years. Per follow-up year, long-term use was found in 3% of the patients with incident OA. Finally, factors associated with more prescriptions were increasing age, OA in ≥2 joint groups [odds ratio (OR) 1.56; 95% CI: 1.51, 1.65] and the presence of other musculoskeletal disorders (OR 4.91; 95% CI: 4.76, 5.05). Men were less likely to be prescribed opioids (OR 0.78; 95% CI: 0.76, 0.80).
conclusionPrescription rates for opioids remained stable, but types of opioids prescribed changed. Oxycodone and fentanyl were increasingly prescribed, while prescriptions of paracetamol/codeine decreased. Since the benefit of opioids for OA pain is questionable and side effects are common, opioids should be prescribed with caution.
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