ArticleJournal of experimental botany2020
Mutations in orthologous PETALOSA TOE-type genes cause a dominant double-flower phenotype in phylogenetically distant eudicots.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 39 citations in OpenAlex.
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- Advancing ornamental plant breeding through genomic technologies: opportunities, challenges, and future directions.Functional & integrative genomics · 2025Review
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- A novel trait to reduce the mechanical damage of peach fruits at harvest: The first genetic dissection study for peduncle length.Molecular breeding : new strategies in plant improvement · 2025Article
- A single dominant GLOBOSA allele accounts for repeated origins of hose-in-hose flowers in Sinningia (Gesneriaceae).The Plant cell · 2024Article
- A glimpse of light on the mystery of regulating temperate fruit tree blooming time.Horticulture research · 2024Article
- Identification of candidate genes associated with double flowers via integrating BSA-seq and RNA-seq in Brassica napus.BMC genomics · 2024Article
- APETALA2-like Floral Homeotic Protein Up-RegulatingInternational journal of molecular sciences · 2024Article
- Molecular and genetic regulation of petal number variation.Journal of experimental botany · 2024Review
- The transcription factor RhMYB17 regulates the homeotic transformation of floral organs in rose (Rosa hybrida) under cold stress.Journal of experimental botany · 2024Article
- Mutations overlying the miR172 target site of TOE-type genes are prime candidate variants for the double-flower trait in mei.Scientific reports · 2024Article
- A 49-bp deletion ofHorticulture research · 2024Article
- Overexpression of lily MicroRNA156-resistantFrontiers in plant science · 2024Article
- Gene-flow investigation between garden and wild roses planted in close distance.Plant biotechnology (Tokyo, Japan) · 2023Article
- Genetic Engineering and Genome Editing Advances to Enhance Floral Attributes in Ornamental Plants: An Update.Plants (Basel, Switzerland) · 2023Review
- Efficient double-flowered gentian plant production using the CRISPR/Cas9 system.Plant biotechnology (Tokyo, Japan) · 2023Article
- Low-Oxygen Responses of Cut Carnation Flowers Associated with Modified Atmosphere Packaging.Plants (Basel, Switzerland) · 2023Article
- The double flower variant of yellowhorn is due to a LINE1 transposon-mediated insertion.Plant physiology · 2023Article
- Candidate genes screening based on phenotypic observation and transcriptome analysis for double flower of Prunus mume.BMC plant biology · 2022Article
- Less is more: natural variation disrupting a miR172 gene at the di locus underlies the recessive double-flower trait in peach (P. persica L. Batsch).BMC plant biology · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The double-flower phenotype has been selected by humans for its attractiveness in various plant species and it is of great commercial value for the ornamental market. In this study we investigated the genetic determinant of the dominant double-flower trait in carnation, petunia, and Rosa rugosa, and identified mutant alleles of TARGET OF EAT (TOE)-type genes characterized by a disruption of the miR172 target sequence and of the C-terminal portion of the encoded protein. Despite the phylogenetic distance between these eudicots, which diverged in the early Cretaceous, the orthologous genes carrying these mutations all belong to a single TOE-type subgroup, which we name as PETALOSA (PET). Homology searches allowed us to identify PET sequences in various other species. To confirm the results from naturally occurring mutations, we used CrispR-Cas9 to induce lesions within the miR172 target site of Nicotiana tabacum PET genes, and this resulted in the development of supernumerary petaloid structures. This study describes pet alleles in economically important ornamental species and provides evidence about the possibility of identifying and engineering PET genes to obtain the desirable double-flower trait in different plants.
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