ArticleNature genetics2020
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation.
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In one paragraph
Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 105 citations in OpenAlex.
- Article
- Direct and indirect regulation of fetal globin transcript by the RNA-binding protein IGF2BP1.Blood · 2026Article
- IMP1 is a novel posttranscriptional regulator of early erythroid development and embryonic globin output.Blood advances · 2026Article
- New Gene Therapy Strategy for β-Thalassemia.Stem cell reviews and reports · 2026Review
- Embryo-scale Visual Cell Sorting reveals a conserved transcriptomic signature of nucleolar size linked to proteostasis.bioRxiv : the preprint server for biology · 2026Article
- COUP-TFII regulates hemoglobin switching by activating the BCL11A-XL repressor LIN28B and directly binding δ and β globin promoters in fetalHaematologica · 2026Article
- Dissecting polycomb complexes for enhanced fetal hemoglobin production.bioRxiv : the preprint server for biology · 2026Article
- Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Review
- Dynamic activity of Erg promotes maturation of the hematopoietic system.Blood advances · 2026Article
- Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells.bioRxiv : the preprint server for biology · 2026Article
- miRNA-Mediated Regulation of γ-Globin to β-Globin Switching: Therapeutic Potential in β-Hemoglobinopathies.International journal of molecular sciences · 2026Review
- Progress and prospect of minicircle as a minimized non-viral DNA vector in gene therapy and regenerative medicine.Molecular therapy. Nucleic acids · 2025Review
- Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1.bioRxiv : the preprint server for biology · 2025Article
- Hepatitis C virus NS3 helicase contributes to (-) strand RNA synthesis.Nature communications · 2025Article
- Cell type-specific purifying selection of synonymous mitochondrial DNA variation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Review
- Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia.Cell stem cell · 2025Article
- Upregulation of miR‑6747‑3p affects red blood cell lineage development and induces fetal hemoglobin expression by targeting BCL11A in β‑thalassemia.Molecular medicine reports · 2025Article
- Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 2 countries.
Anindita Basak *Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. abasak@broadinstitute.org.ORCID http://orcid.org/0000-0002-7046-4500
Mathias Munschauer *Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6143-4548
Caleb A LareauDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kara E MontbleauDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jacob C UlirschDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7947-0827
Christina R HartiganBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Monica SchenoneBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6456-8768
John LianInstitute for Biomedical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yaomei WangNew York Blood Center, New York, NY, USA.
Yumin HuangNew York Blood Center, New York, NY, USA.
Xianfang WuThe Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Lee GehrkeInstitute for Biomedical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Charles M RiceThe Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Xiuli AnNew York Blood Center, New York, NY, USA.
Helen A ChristouDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital and Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Narla MohandasNew York Blood Center, New York, NY, USA.
Steven A CarrBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7203-4299
Jane-Jane ChenInstitute for Biomedical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4372-6907
Stuart H OrkinDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Eric S LanderBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2662-4631
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.ORCID http://orcid.org/0000-0003-0044-443X
Broad Institute · USNew York Blood Center · USHarvard–MIT Division of Health Sciences and Technology · USRockefeller University · USBrigham and Women's Hospital · US
Funding
YEAST MEMBRANE CYTOSKELETONP01DK032094 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NARLA, MOHANDAS · 1987 to 2021
$26.7MMOLECULAR ANALYSIS OF NORMAL AND TYHALASSEMIC DNAR01HL032259 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ORKIN, STUART H · 1985 to 2022
$8.8MTranslational and clinical studies targeting y-globin modulationU01HL117720 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SANKARAN, VIJAY GANESH · 2013 to 2017
$7.4MSystematic Genetic Dissection of Human ErythropoiesisR01DK103794 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Vijay Ganesh Sankaran · 2014 to 2026
$5.9MHRI-eIF2a Phosphorylation Signaling in Oxidative Stress and ErythropoiesisR01DK087984 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHEN, JANE-JANE · 2010 to 2017
$2.1MIdentifying Genome-wide Association Study-Nominated Regulators of ErythropoiesisR33HL120791 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SANKARAN, VIJAY GANESH · 2016 to 2018
$1.7MNHLBI NIH HHS R01 HL032259NHLBI NIH HHS R33 HL120791NHLBI NIH HHS U01 HL117720NIDDK NIH HHS P01 DK032094NIDDK NIH HHS R01 DK087984NIDDK NIH HHS R01 DK103794
Abstract
Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia
Indexed as
AdultAnimalsBinding SitesCells, CulturedErythroid CellsErythropoiesisGene Expression RegulationHemoglobinsHumansInfant, NewbornMicroRNAsProtein BiosynthesisRepressor ProteinsRibosomesRNA-Binding ProteinsRNA, MessengerBCL11A protein, humanHemoglobinsLIN28B protein, humanMicroRNAsmirnlet7 microRNA, humanRepressor ProteinsRNA-Binding ProteinsRNA, MessengerRNA, Ribosomal, 18S
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.