ArticleNature medicine2020
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
Erratum issuedOpen access · greenAbstract readCase Reports
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- Utilising human cellular models of primary ciliary dyskinesia: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026Article
- The Value of Nasal Nitric Oxide Measurement in the Diagnosis of Primary Ciliary Dyskinesia.Pediatric pulmonology · 2026Review
- Ciliary Beat Frequency and Pattern: An Accessible Tool for the Screening of Primary Ciliary Dyskinesia.Diagnostics (Basel, Switzerland) · 2026Article
- NIMA-related kinase family at the nexus of skeletal development and congenital arthrogryposis: coordinated regulation of cell cycle and ciliary dynamics.Frontiers in genetics · 2026Review
- Primary ciliary dyskinesia phenotypes and correlation with genotype.Current opinion in pulmonary medicine · 2025Review
- NEK Family Kinases: Structure, Function, and Role in Disease.Biomolecules · 2025Review
- Hedgehog pathway, cell cycle, and primary cilium.Cell death discovery · 2025Review
- Article
- NEK8, a NIMA-family protein kinase at the core of the ciliary INV complex.Cell communication and signaling : CCS · 2025Review
- Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling.bioRxiv : the preprint server for biology · 2025Article
- The BBS/CCT chaperonin complex ensures the localization of the adhesion G protein-coupled receptor ADGRV1 to the base of primary cilia.Frontiers in cell and developmental biology · 2025Article
- Clinical, phenotype and genotype correlations in primary ciliary dyskinesia suspected children in Egypt.Frontiers in molecular biosciences · 2025Article
- Review
- NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status.Proteome science · 2024Article
- A lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescence.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons.The Journal of cell biology · 2024Article
- Development and Initial Characterization of Pigs withbioRxiv : the preprint server for biology · 2024Article
- Primary Ciliary Dyskinesia.Pediatrics · 2024Review
- Article
- β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 6 institutions in 3 countries.
Raghu R ChivukulaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. raghu@wi.mit.edu.ORCID http://orcid.org/0000-0001-5264-3196
Daniel T MontoroBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Hui Min LeungWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Jason YangWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Hanan E ShamseldinDepartment of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Martin S TaylorWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Gerard W DoughertyDepartment of General Pediatrics, University Children's Hospital Muenster, Münster, Germany.
Maimoona A ZariwalaDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Johnny CarsonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
M Leigh Anne DanielsDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6979-2681
Patrick R SearsCystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Katharine E BlackDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Lida P HaririDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Ibrahim AlmogarriDepartment of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Evgeni M FrenkelWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Vladimir VinarskyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Heymut OmranDepartment of General Pediatrics, University Children's Hospital Muenster, Münster, Germany.
Michael R KnowlesCystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Fowzan S AlkurayaDepartment of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. falkuraya@kfshrc.edu.sa.ORCID http://orcid.org/0000-0003-4158-341X
David M SabatiniWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1446-7256
Broad Institute · USUniversity of North Carolina at Chapel Hill · USKing Faisal Specialist Hospital & Research Centre · SAMassachusetts General Hospital · USHarvard University · USUniversity Hospital Münster · DE
Funding
The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Maurizio Macaluso · 2019 to 2026
$51.2MLongitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary DyskinesiaU54HL096458 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIS, STEPHANIE DUGGINS, FERKOL, THOMAS W · 2009 to 2023
$20.0MUNC Clinical and Translational Science AwardUL1TR000083 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2012 to 2013
$11.6MMOLECULAR IMMUNOLOGY AND TUMOR BIOLOGYT32CA009216 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Michael Langenau · 1985 to 2026
$10.6MResearch Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6MPathogenesis of PCD Lung DiseaseR01HL071798 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNOWLES, MICHAEL R · 2004 to 2021
$7.2MRegulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MCell Growth Signaling in Cancer DevelopmentR01CA129105 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2008 to 2021
$5.9MTRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALINGR01AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2000 to 2021
$4.9MNovel Components of the mTORC1 and mTORC2 PathwaysR37AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SABATINI, DAVID M. · 2010 to 2019
$4.8MFunctional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to PhenotypeR01HL117836 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OSTROWSKI, LAWRENCE E · 2013 to 2023
$4.4MEpithelial cell activation of fibroblasts in pulmonary fibrosisK08HL133603 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BLACK, KATHARINE E. · 2016 to 2020
$868kNCATS NIH HHS U2C TR002818NCATS NIH HHS UL1 TR000083NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA129105NCI NIH HHS T32 CA009216NHLBI NIH HHS K08 HL133603NHLBI NIH HHS R01 HL071798NHLBI NIH HHS R01 HL117836NHLBI NIH HHS T32 HL116275NHLBI NIH HHS U54 HL096458NIAID NIH HHS R01 AI047389NIAID NIH HHS R37 AI047389NIH HHS S10 OD012027
Abstract
Mucociliary clearance, the physiological process by which mammalian conducting airways expel pathogens and unwanted surface materials from the respiratory tract, depends on the coordinated function of multiple specialized cell types, including basal stem cells, mucus-secreting goblet cells, motile ciliated cells, cystic fibrosis transmembrane conductance regulator (CFTR)-rich ionocytes, and immune cells
Indexed as
Mucociliary ClearanceAdolescentAdultCell SeparationChildCiliopathiesCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsExomeFemaleFlow CytometryHEK293 CellsHomozygoteHumansMicroscopy, Phase-ContrastMicroscopy, VideoCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorNek10 protein, humanNIMA-Related KinasesProteome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.