ArticleNature medicine2020
Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report.
Open access · greenAbstract readCase Reports
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
10.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Fatal outcome related to drug reaction with eosinophilia and systemic symptoms: a disproportionality analysis of FAERS database and a systematic review of cases.Frontiers in immunology · 2024Pooled it
- In Vitro Monitoring of Human T Cell Responses to Skin Sensitizing Chemicals-A Systematic Review.Cells · 2021Pooled it
- Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.Drugs · 2026Review
- Acute fever and rash in Anti-MDA5Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Article
- Characterization of Ovarian Cell Types and Molecular Signatures in Mauremys reevesii Using Single-Cell Sequencing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Suspected upadacitinib-associated drug hypersensitivity mimicking disease exacerbation in ulcerative colitis.Clinical journal of gastroenterology · 2026Article
- Review
- JAK inhibition may prevent drug hypersensitivity reactions.JCI insight · 2026Article
- DC subsets and states unraveled across human juxtatumoral and malignant tissues.Nature immunology · 2026Article
- Evaluating Baricitinib for Severe Paediatric Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) with Single-Cell Sequencing.Journal of inflammation research · 2026Article
- Targeted therapy against recurrent anti-synthetase syndrome associated interstitial lung disease after bilateral lung transplantation guided by transcriptomic analyses: a case-based study.Frontiers in immunology · 2026Article
- hECA v2.0: an AI-ready ensemble cell atlas of single-cell RNA and ATAC sequencing data.Scientific data · 2025Article
- Recent advancements in tissue dissociation techniques for cell manufacturing single-cell analysis and downstream processing.Stem cells translational medicine · 2025Review
- Advancing Precision Medicine in Inflammatory Skin Disease.American journal of clinical dermatology · 2025Review
- A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues.Nature immunology · 2025Article
- Artificial Intelligence-Driven Nanoarchitectonics for Smart Targeted Drug Delivery.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Single-Cell Transcriptomic Analysis Reveals Cell Heterogeneity and Altered Signaling Pathways in Jellyfish Sting Patients.Marine drugs · 2025Article
- Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology.Aging and disease · 2025Review
- TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity.Signal transduction and targeted therapy · 2025Article
- The spatial and single-cell landscape of skin: Charting the multiscale regulation of skin immune function.Seminars in immunology · 2025Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 2 countries.
Doyoung KimCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA.
Tetsuro KobayashiCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA.
Benjamin VoisinCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA.
Jay-Hyun JoCutaneous Microbiome and Inflammation Section, Dermatology Branch, NIAMS, National Institutes of Health (NIH), Bethesda, MD, USA.
Keiko SakamotoCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA.
Seon-Pil JinCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA.
Michael KellyCancer Research Technology Program, Single-Cell Analysis Facility, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Helena B PasiekaDepartment of Dermatology, MedStar Washington Hospital Center & Georgetown University Hospital, Washington, DC, USA.
Jessica L NaffDepartment of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Jon H MeyerleDepartment of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Ijeoma D IkpeamaDepartment of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
Gary A FahleDepartment of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
Fred P DavisMolecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA.
Sergio D RosenzweigImmunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
Julie C AlejoLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Stefania PittalugaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Heidi H KongCutaneous Microbiome and Inflammation Section, Dermatology Branch, NIAMS, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4424-064X
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
Keisuke NagaoCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA. keisuke.nagao@nih.gov.ORCID http://orcid.org/0000-0002-7005-3138
National Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institutes of Health · USNational Institutes of Health Clinical Center · USNational Cancer Institute · USWalter Reed National Military Medical Center · USFrederick National Laboratory for Cancer Research · USMedStar Washington Hospital Center · USNational Institute of Allergy and Infectious Diseases · USYonsei University · KR
Funding
Studies of Inherited Causes of Fungal SusceptabilityZIAAI001122 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENZWEIG, SERGIO · 2010 to 2025
$26.0MExploring mechanisms that govern immune homeostasis in skinZIABC011561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NAGAO, KEISUKE · 2014 to 2021
$10.1MPrimary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7MCutaneous Adverse Drug ReactionsZIABC010940 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2009 to 2021
$603kCCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011561NCI NIH HHS HHSN261200800001E
Abstract
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases
Indexed as
Single-Cell AnalysisTranscriptomeAdrenal Cortex HormonesAdultAntiviral AgentsAutoimmune DiseasesCD4-Positive T-LymphocytesCell ProliferationCell SeparationDrug Hypersensitivity SyndromeFlow CytometryHerpesvirus 6, HumanHumansImmunosuppressive AgentsLeukocytes, MononuclearLymphocytesAdrenal Cortex HormonesAntiviral AgentsImmunosuppressive AgentsPiperidinesPyrimidinesPyrrolestofacitinibVDJ Recombinases
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.